Meibomian gland dysfunction (MGD) may well be the leading cause of dry eye disease throughout the world. Although this condition affects the health and well-being of millions of people, there is no global consensus on the definition, classification, diagnosis, or therapy for MGD. To achieve such a consensus, the Tear Film and Ocular Surface Society (TFOS; http://www.tearfilm.org), a nonprofit o...

Introduction Meibomian Gland Dysfunction (MGD) is a common, often overlooked, chronic condition affecting eyes for which various therapies are being evaluated. Considering the absence of a systematic review and meta-analysis, the present review was carried out. Methods An appropriate search strategy eligibility criteria were framed and electronic databases were scrutinized for appropriate lit...

Meibomian gland carcinomas are very rare and constitute 1% of all malignant tumors of the eye lid. They are often mistaken for Chalazion and excised. It’s malignant nature being recognized only when it recurs repeatedly. They are locally invasive and metastasize to liver brain and lymph nodes. A case of adenocarcinoma of meibomian sebaceous gland with post operative metastases to parotid gland ...

Evaporative dry eye has gained increasing interest in recent years in academia, pharmaceutical, and medical device industries. The main cause of this type of dry eye is attributed to meibomian gland dysfunction (MGD). MGD is a diffuse abnormality of the meibomian glands characterised by terminal duct obstruction and eventually leading to signs and symptoms of dry eye. There have been only a few...

Rabbit whole meibomian glands were isolated by microsurgical dissection and enzymatic digestion. Both ductal and acinar elements could be separated by subsequent microsurgical manipulation. Epithelial outgrowth could be derived from either the whole gland or the ductal/acinar elements using collagen gel in the serum-containing, growth factor-enriched medium. Two types of outgrowths were observe...

BACKGROUND Posterior blepharitis is an eyelid disease primarily of the meibomian glands. Bacteria and chronic inflammation are contributing factors for meibomian gland disease, which leads to ocular surface and tear film alterations and chronic patient symptoms. Azithromycin 1.0% ophthalmic solution is a broad spectrum topical antibiotic with anti-inflammatory properties. The present study eval...

PURPOSE The purpose of this study was to characterize the natural history of meibomian gland morphogenesis in the mouse. METHODS Embryonic (E) and post natal (P) C57Bl/6 mouse pups were obtained at E18.5, P0, P1, P3, P5, P8, P15, and P60. Eyelids were fixed and processed for en bloc staining with Phalloidin/DAPI to identify gland morphogenesis, or frozen for immunohistochemistry staining with...

PURPOSE Lubricin is a principal boundary lubricating and anti-adhesion protein found in synovial fluid and several musculoskeletal tissues. This study investigates the presence of lubricin in the meibomian gland, lacrimal gland and ocular surface of healthy rabbits; prompted by the hypothesis that lubricin acts as boundary lubricant and anti-adhesive protein in the eye. METHODS Thirty six eye...