Background: Ultrasound-stimulated microbubbles (USMB) have shown potential for enhancing radiation treatment via cavitation and sonoporation mechanisms. However, in vitro studies produced inconsistent results, with adherent cells demonstrating no radioenhancement. This study aims to investigate the effect of cell adherence on radioenhancement using USMB radiation. Method: Lung metastases follic...

This paper reports on the commissioning of an Elekta cone-beam computed tomography (CT) system at one of the first U.S. sites to install a "regular," off-the-shelf Elekta Synergy (Elekta, Stockholm, Sweden) accelerator system. We present the quality assurance (QA) procedure as a guide for other users. The commissioning had six elements: (1) system safety, (2) geometric accuracy (agreement of me...

Objective(s): Taking advantage of high atomic number of gold nanoparticles (GNPs) in radiation dose absorbing, many in vitro and in vivo studies have been carried out on using them as radio-sensitizer. In spite of noticeable dose enhancement by GNPs at keV energies, using this energy range for radiotherapy of deep-seated tumors is outdated. The aim of the present work was to examine the effect ...

JULY/AUGUST 2010 ADVANCED OCULAR CARE 33 R adiation therapy has been evaluated extensively as a treatment for choroidal neovascularization (CNV) due to age-related macular degeneration (AMD) because of its antiangiogenic, antifibrotic, and anti-inflammatory properties.1-3 Historically, radiation for AMD has been delivered with two broad approaches: (1) radiotherapy with external beam (megavolta...

Introduction: In order to reduce patient setup error in treatment field, portal images with treatment beam (megavoltage x-ray) are widely used. These images are acquired by electronic portal imaging devices (EPID). However, portal images suffer from insufficient anatomical information, contrast, and spatial resolution, because of the fact that Compton scatter is the main photon...

During the radiotherapy process, the emergence of set-up errors is nearly inevitable. Because set-up errors were not detected and corrected daily, planned target volumes were formed by expanding the clinical target volume according to each unit's experience. We optimized the margins of clinical and planned target volumes during administration of intensity-modulated radiotherapy for nasopharynge...

BACKGROUND To analyze setup deviations using daily megavoltage computed tomography (MVCT) and to evaluate three MVCT frequency reducing protocols for gynecologic cancer patients treated with helical tomotherapy. METHODS We recorded the setup errors of 56 patients with gynecological cancer observed throughout their whole course by matching their daily MVCT with the planning CT. Systematic and ...

Currently portal imaging devices are used to obtain information on patient localization during radiation therapy treatments. Such obtained information is two dimensional in nature, limited to the plane of the captured image. It has been proposed that megavoltage computed tomography images be reconstructed to overcome this limitation. This study explores the feasibility of reconstructing tomogra...