BACKGROUND Oesophageal motility is often impaired in patients with megaduodenum and other forms of intestinal pseudo-obstruction in which a visceral myopathy or neuropathy may be present. Idiopathic longstanding megacolon with onset in adult life is still a poorly defined entity, which may also be part of a more widespread motility disorder but in which oesophageal motility has not been yet sys...

It has been assumed that in piebald lethal mice that develop megacolon, impaired colonic motor activity is restricted to the aganglionic distal colon. Peristaltic mechanical recordings, immunohistochemistry, and quantitative PCR were used to investigate whether regions of the colon, other than the aganglionic segment, may also show anatomical modifications and dysfunctional colonic motor activi...

Latar belakang: Megacolon congenital atau hirschprung disease merupakan penyebab umum obstruksi usus neonatal di mana segmen dari saluran bagian distal tidak memiliki elemen sistem saraf enterik yang normal. Transanal endorecral pull-through (TAERPT) salah satu prosedur operasi sebagai tatalaksana megacolon sering dipakai karena metodenya invasif minimal dan memberikan efek kosmetik lebih baik ...