While endodontic (dentoalveolar) abscesses can cause significant morbidity, in susceptible individuals they can pose life-threatening problems. This paper provides an overview of the more serious sequelae of endodontic abscesses, and provides examples of ‘high risk’ situations in practice in which these serious complications are more likely to occur.

We report on the integration of Tps as an external reasoning component into the mathematical assistant system mega. Thereby Tps can be used both as an automatic theorem prover for higher order logic as well as interactively employed from within the mega environment. Tps proofs can be directly incorporated into mega on a tactic level enabling their visualization and verbalization. Using an examp...

The skin represented the dose-limiting organ in radiotherapy over long periods of time. In the first third of the 20th century, radiotherapy was associated with deposition of significant radiation doses in the superficial compartments of the skin. Therefore, all major radiobiological principles, such as effects of fractionation on radiation sensitivity or volume/area effects, were initially bas...

The possible dose-dependency for the antidepressant effect of selective serotonin reuptake inhibitors (SSRIs) remains controversial. We believe we have conducted the first comprehensive patient-level mega-analysis exploring this issue, one incentive being to address the possibility that inclusion of low-dose arms in previous meta-analyses may have caused an underestimation of the efficacy of th...

The Molecular Evolutionary Genetics Analysis (MEGA) software is a desktop application designed for comparative analysis of homologous gene sequences either from multigene families or from different species with a special emphasis on inferring evolutionary relationships and patterns of DNA and protein evolution. In addition to the tools for statistical analysis of data, MEGA provides many conven...

Summary : Detecting significant associations between genetic variants and disease may prove particularly challenging when the variants are rare in the population and/or act together with other variants to cause the disease. We have developed a statistical framework named Mutation Enrichment Gene set Analysis of Variants (MEGA-V) that specifically detects the enrichments of genetic alterations w...

A new robust clustering scheme based on fuzzy c-means is proposed and the concept of a fuzzy mega-cluster is introduced in this paper. The fuzzy mega-cluster is conceptually similar to the noise cluster, designed to group outliers in a separate cluster. This proposed scheme, called the mega-clustering algorithm is shown to be robust against outliers. Another interesting property is its ability ...

Mega-projects figure prominently in the arsenal of contemporary city-building strategies. The allure is of a city redefined, placed on the world stage and able to improve services, facilities and revenues. Community attitudes to such projects are often mixed, with fears of gentrification, displacement or loss of existing city character. Although mega-projects are adopted to pursue global ambiti...