Fluorescence from the beads was easily detectable by fluorescence photomicroscopy when the amount of translation reaction added to an immunoprecipitation corresponded to as little as 1 nl per bead (Fig. 1c). This is equivalent to about 2 × 10 6 protein molecules per bead, giving a surface density of about 80 molecules per ␮m 2. Even a density as low as about 8 molecules per ␮m 2 could be seen i...

Obstructive sleep apnea (OSA) is one of the most common diseases among Americans, affecting between 5 and 20% of the population. While there is existing evidence of numerous comorbid conditions, such as obesity, diabetes, and high blood pressure, the vast majority of this evidence has focused explicitly on cardiovascular morbidities and excluded any mental or behavioral disorders. The goal of t...

MOTIVATION The MEDLINE database, consisting of over 19 million publication records, is the primary source of information for biomedicine and health questions. Although the database itself has been growing rapidly, the search paradigm of MEDLINE has remained largely unchanged. RESULTS Here, we propose a new system for exploring the entire MEDLINE collection, represented by two unique features:...

The MEDLINE database is the world largest repository of bio-medical abstracts. It is a central information entry point for most biologists despite the growing availability of full-text articles on the WWW. Each article is manually annotated by MeSH terms to allow easy access and in order to improve retrieval, the MeSH fields of MEDLINE records were successfully used in the past with pseudo-rele...

This study compared in-house Grateful Med database use and searching success rates for four-month periods at four sites of the Library of the Health Sciences of the University of Illinois at Chicago. Data were collected from Grateful Med workstation uselogs and analyzed. Database use patterns and searching success rates were fairly consistent across the four sites. Though MEDLINE was available ...