background: melanoma causes the greatest morbidity and mortality of all skin cancers. mucosal melanoma is a rare but highly aggressive neoplasm. according to previous studies the prevalence of kit mutations in acrallentiginous and mucosal melanomas is relatively low (less than 15–20%), but it can have profound therapeutic implications for localized high risk or metastatic diseases. our goal was...

The increasing use of electronic health records (EHR) has allowed for an unprecedented ability to perform analysis on patient data. By training a number of statistical machine learning classifiers over the unstructured text found in admission notes and operating procedures, prediction of a surgical procedure’s outcome can be performed. We extend an initial bag-of-words model to a bag-of-concept...

Department of Zoology, University of Cape Town, Private Bag, Rondebosch, 7701, South Africa (CMM-B, DSJ, MCS) Division of Chemical Pathology, University of Cape Town Medical School, Observatory, 7925, South Africa (CMM-B, EHH) Evolutionary Genomics Group, Department of Botany and Zoology, University of Stellenbosch, Private Bag X1, Matieland, Stellenbosch, 7602, South Africa (GE) Present addres...

Cancer of Cowper's gland is a very rare cancer. This case represents the 9th case in the medical literature. As such, there are no phase II or phase III trials to guide treatment. In this article, we report the successful treatment of a patient over a 7-year period guided solely by molecular profiling. Through multiple cycles to treatment, the cancer was controlled using drugs targeting c-kit, ...

BACKGROUND AND OBJECTIVES The well-known advantages of minimally invasive surgery make the approach well suited for hysterectomy and other gynecological procedures. The removal of specimens excised during surgery has been a challenge that has been answered by the use of power morcellation. With this study we sought to assess the feasibility of power morcellation within a specimen bag. METHODS...

BACKGROUND/AIMS The diagnosis of gastrointestinal stromal tumors (GIST) relies on the demonstration of KIT expression, but KIT expression is absent or reduced in approximately 15% of GIST. METHODS Eighty-one GISTs were diagnosed between January 1998 and December 2007 at the Department of Pathology at both Chungnam National University Hospital and Eulji University Hospital, Daejeon. Medical hi...

Text classification in the medical domain is a real world problem with wide applicability. This paper investigates extensively the effect of text representation approaches on the performance of medical document classification. To accomplish this objective, we evaluated seven different approaches to represent real word medical documents. The text representation approaches investigated in this pa...

E100 CMAJ, January 10, 2012, 184(1) © 2012 Canadian Medical Association or its licensors When students asked the celebrated Sir William Osler about the role of the physician of the day, he is quoted as saying “diagnosis, diagnosis and diagnosis.” Consistent with this, 80% of the 67 original articles in Volume 1 of the Canadian Medical Association Journal related to the description and diagnosis...