Most problems in logic synthesis are computationallyhard, and are solved using heuristics. This often makes algorithms un-stable; if the input is changed slightly, the new result of synthesis can be significantly different. A designer can spend much effort hand-optimizing a circuit, so it is desirable to retain as much of this human insight as possible. This motivates the need for incremental s...

the production of colony-stimulating factors (csf) is delicately controlled through a complex network of humoral and environmental factors. we have studied some of the mechanisms which regulate the production of csf as compared to general protein synthesis in the lung tissue ill vitro. when lung tissue from mice was cultured for various times in serum free medium, the first detectable level of ...

substituted naphthofurans and naphthopyrans were constructed at high temperature from allyl or propargyl naphthyl ethers via claisen rearrangement in moderate to good yields. also, substituted (trimethylsilyl)-naphthofurans were synthesized from the corresponding naphtofurans.

a new, high yielding method for the preparation of vasicinone (7) is described. reaction of 2-nitrobenzoic acid with n, n¢-carbonyldiimidazole followed by 2-pyrrolidinone gave 1-(2-nitrobenzoyl)pyrrolidine-2-one (3). reduction of the latter with 10% pd-c afforded deoxyvasicinone (4). reaction of deoxyvasicinone (4) with bromine yielded monobromo-deoxyvasicinone (5). exchange of bromine of 5 wit...

objective(s): alzheimer's disease (ad) is a neurodegenerative disorder in elderly patients. decrease in cholinergic neurotransmission is the main known cause in the pathophysiology of the disease. improvement and potentiation of the cholinergic system could be beneficial for treatment of the ad. acetylcholinesterase inhibitors such as donepezil can enhance the duration of action of acetylc...

objective(s):according to the prevalence of neoplastic diseases, there is a deep necessity for discovery of novel anticancer drugs in the field of medicinal chemistry. in the current study, a new series ofphenylthiazole derivatives(compounds 4a-4f) was synthesizedand theiranticancer activity was assessed in vitro. materials and methods:all synthesized derivatives were evaluated towards three hu...

nitrofurazone is one of the antibacterial nitrofuran agents used topically for skin infections. the drug is effective on the majority of infectious microorganisms. because of the importance of this drug in clinic, in this study various methods of synthesis of nitrofurazone were examined and the most appropriate method, applicable to pharmaceutical industry was chosen and optimized from the poin...

nano technology has a large number of applications in different fields of science and technology. nano particle are the tiny particles which are being used in upcoming technology due to their small size and high capability. the properties of nanoparticles depend largely on their synthesis procedures. there are different methods for the synthesis of nano particles using different conditions. in ...

amidoalkyl-2-naphthols as synthetic intermediates play an important role in medicinal chemistry due to their remarkable biological and many pharmacological properties. owing to the versatile biological activities, industrial and synthetic applications of these compounds, introduction of an alternative methodology is urgent in synthetic organic chemistry. low yield and harsh reaction conditions ...

the use of biogenic selenium nanoparticles for various purposes is going to be an issue of considerable importance; thus, appropriate simple methods should be developed and tested for the synthesis and recovery of these nanoparticles. in this study, a fungus was isolated from a soil sample, identified as aspergillus terreus and used for extracellular synthesis of selenium nanoparticles (se nps)...