The daughter cyst sign is a specific indicator of an uncomplicated ovarian cyst and pathologically represents a stimulated ovarian follicle. This finding must be differentiated from an ectopic pregnancy in a patient who has the potential to become pregnant. We report an uncomplicated ovarian cyst in a 3-year-old female with McCune-Albright syndrome and precocious puberty mimicking an ectopic pr...

Cushing syndrome is uncommon in childhood and rare in infancy. We report the case of a 3-yr-old child who presented with symptoms of Cushing syndrome beginning shortly after birth. Her hypercortisolemia was cyclical, causing relapsing and remitting symptoms, which eventually led to suspicions of possible Munchausen syndrome by proxy. Investigation at the National Institutes of Health excluded e...

The first three disorders discussed are abnormalities of bone: too little bone in cleidocranial dysplasia caused by mutations in RUNX2; too much bone in fibrodysplasia ossificans progressiva with overexpression of BMP4; and abnormal bone in McCune-Albright syndrome and fibrous dysplasia caused by mutations in GNAS1. Disorders of the sonic hedgehog signaling network are discussed next, including...

The incidence of sexual precocity is 1:10,000, yet previous puberty is infrequently reported. We report a unique case of a young child presenting to the Dermatology clinic for management of acne vulgaris and precocious puberty prompting further work-up to evaluate for McCune Albright Syndrome. While primarily idiopathic, we discuss the associated dermatologic conditions that should be considere...

An important question with a rich history is the extent to which the symplectic category is larger than the Kähler category. Many interesting examples of non-Kähler symplectic manifolds have been constructed [T] [M] [G]. However, sufficiently large symmetries can force a symplectic manifolds to be Kähler [D] [Kn]. In this paper, we solve several outstanding problems by constructing the first sy...