BACKGROUND The effect of sentinel lymph node status on survival in patients with Merkel cell carcinoma (MCC) of the head and neck is uncertain. METHODS We used the Surveillance Epidemiology and End Results (SEER) database to identify patients with MCC who underwent sentinel lymph node biopsy (SLNB). Clinicopathologic data and disease-specific survival (DSS) were compared among patients with p...

A novel greener method to impregnate silver nanoparticles (AgNPs) into microcrystalline cellulose (MCC) by curry leaf (Murraya koenigii) extract is presented. The active reduction of silver ions by curry leaf extract was explored for the in situ impregnation AgNPs into MCC. Transmission electron microscopy (TEM) analysis of MCC coated with AgNPs showed the formation of silver particle sizes in ...

Merkel cell carcinoma (MCC) is an aggressive, cutaneous, neuroendocrine carcinoma and, in rare cases, occurs with Bowen's disease (BD). In this report, we describe a case of MCC concurrent with invasive BD and compare the profiles of tumor-infiltrating leukocytes in the lesional skin of MCC and invasive BD. Interestingly, immunohistochemical study revealed significant numbers of CD8+ cells and ...

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumor of the skin currently with no cure. In this study, we have first demonstrated that c-Myc overexpression is common in MCC. By targeting c-Myc, bromodomain inhibitors have demonstrated antitumor efficacy in several preclinical human cancer models. Thus, we interrogated the role of c-Myc inhibition in MCC with c-Myc amplification by...

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer. Pathologic activation of PI3K/mTOR pathway and elevated expression of c-Myc are frequently detected in MCC. Yet, there is no targeted therapy presently available for this lethal disease. Recently, MLN0128, a second-generation dual TORC1/2 inhibitor is shown to have therapeutic efficacy in preclinical studies. MLN0128 is cu...

Merkel cell carcinoma (MCC) is the most aggressive skin cancer. Recently, it was demonstrated that human Merkel cell polyomavirus (MCV) is clonally integrated in approximately 80% of MCC tumors. However, direct evidence for whether oncogenic viral proteins are needed for the maintenance of MCC cells is still missing. To address this question, we knocked down MCV T-antigen (TA) expression in MCV...

Mobile cloud computing (MCC) is a relatively new concept that leverages the combination of cloud technology, mobile computing, and wireless networking to enrich the usability experiences of mobile users. Many field of application such as mobile health, mobile learning, mobile commerce and mobile entertainment are now taking advantage of MCC technologies. Since MCC is new, there is need to advan...

Merkel cell carcinoma (MCC) is a rare cutaneous malignancy occurring mostly in older immunocompromized Caucasian males. A growing incidence of MCC has been reported in epidemiological studies. Treatment of MCC usually consists of surgical excision, pathological lymph node evaluation, and adjuvant radiotherapy. This paper reports the experience of a single tertiary center institution with 17 hea...