نتایج جستجو برای: mb468
تعداد نتایج: 55 فیلتر نتایج به سال:
BACKGROUND The majority of cancer cells have a unique metabolic requirement for methionine that is not observed in normal, non-tumorigenic cells. This phenotype is described as "methionine dependence" or "methionine stress sensitivity" in which cancer cells are unable to proliferate when methionine has been replaced with its metabolic precursor, homocysteine, in cell culture growth media. We fo...
(MAP2K3, MKK3) is a member of the dual-specificity protein kinase group (MKK) that belongs to the mitogen-activated protein kinase (MAPK) signaling pathway. Following different forms of stressful stimuli and inflammatory cytokines, MKK3 is activated through phosphorylation on serine and threonine residues at sites Ser189 and Thr193 by MKKK proteins (MEKK 1-4) [1]. Activated MKK3 phosphorylates ...
background cancer stem cells play crucial roles in resistance to therapeutic schemes and relapse of disease, so it is important to find targeted therapies that kill them selectively. breast cancer is the most common cancer in females living in all part of the world including iran and it has an important burden in public health with direct impact on patients’ families. breast cancer in young adu...
The nucleoside adenosine is present within cells and body fluids of all living organisms and its production, both intra- and extracellularly, is tightly coupled to energy consumption resulting in increased level of extracellular adenosine. The physiological effects of adenosine are mediated through four pharmacologically and biochemically distinct adenosine receptors (AR), i.e. A1, A2A, A2B and...
This study investigated the hepatoprotective and antioxidant response to intraperitoneal, intravenous, subcutaneous and oral treatment with quercetin in adult male Wistar rat. The animals were divided randomly into the four groups according to the routes of administration. Quercetin was allowed to react with selected hepatic isoenzymes (aspartate amino transferase, alanine amino transferase) vi...
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