the present investigation was focused to formulate semi-solid capsules (sscs) of hydrophobic drug telmisartan (tlms) by encapsulating semi-solid matrix of its solid dispersion (sd) in hpmc capsules. the combinational approach was used to reduce the lag time in drug release and improvise its dissolution. sds of tlms was prepared using hot fusion method by varying the combinations of pluronic-f68...

An extraction technique is described for vitamin K1 in medical foods, using accelerated solvent extraction (ASE) in conjunction with matrix solid-phase dispersion (MSPD). The medical food sample is treated as it would be with MSPD extraction, followed by ASE for a hands-free automated extraction. The vitamin K1 in the ASE extract is then quantitated by reversed-phase liquid chromatography with ...

A liquid chromatographic method for vitamin K1 in milk-based infant formula is described. The vitamins are extracted from infant formula by matrix solid-phase dispersion and quantitated by reversed-phase chromatography with fluorescence detection. Vitamin K1 is converted to the fluorescent hydroquinone with a postcolumn zinc reductive reactor. The limit of detection is 12 pg, and the limit of q...

This licentiate thesis is based on two papers that describe two original methods for analysing environmental pollutants. In both cases samples were extracted by onor off-line Matrix Solid Phase Dispersion (MSPD), then target analytes were separated from potentially interfering matrix components and analysed by Liquid Chromatography–Mass Spectrometry (LC-MS). Hot water and a small volume of meth...

Determination of benzo(a)pyrene in vegetable oils was carried out using aluminium oxide for clean-up followed by reverse phase high performance liquid chromatographic (HPLC). A quantity of oil was dissolved in petroleum ether and added to an aluminium oxide column which retained the lipids. Benzo(a)pyrene in the oil was eluted from the column with petroleum ether and the collected eluate was co...

The present investigation was focused to formulate semi-solid capsules (SSCs) of hydrophobic drug telmisartan (TLMS) by encapsulating semi-solid matrix of its solid dispersion (SD) in HPMC capsules. The combinational approach was used to reduce the lag time in drug release and improvise its dissolution. SDs of TLMS was prepared using hot fusion method by varying the combinations of Pluronic-F68...