This research provides a longitudinal view of early childhood economic deprivation and its associations with health among young Hispanic children born in the United States. Of additional interest is whether economic deprivation is associated with child health similarly across all Hispanic children or whether associations differ by maternal nativity or country of origin. Fragile Families and Chi...

The fetal genome regulates maternal physiology and behavior via its placenta, which produces hormones that act on the maternal hypothalamus. At the same time, the fetus itself develops a hypothalamus. In this study we show that many of the genes that regulate placental development also regulate the developing hypothalamus, and in mouse the coexpression of these genes is particularly high on emb...

BACKGROUND Gestational diabetes mellitus (GDM) occurs in 2-6 % of all pregnancies. We investigated whether area level deprivation is associated with a higher risk for GDM and whether GDM detection rates in deprived regions changed after the introduction of charge-free GDM screening in Germany in 2012. METHODS We analyzed population-based data from Bavaria, Germany, comprising n = 587,621 deli...

OBJECTIVE In this study, the effect of maternal deprivation (MD) and chronic unpredictable stress (CUS) in inducing depressive behaviors and associated molecular mechanism were investigated in rats. METHODS Maternal deprivation was established by separating pups from their mothers for 6 hours daily from postnatal day 1 to day 14. Chronic unpredictable stress was established by water deprivati...

BACKGROUND Although maternal perinatal mental illnesses commonly present to and are primarily treated in general practice, few population-based estimates of this burden exist, and the most affected socioeconomic groups of pregnant women remain unclear. AIM To provide estimates of maternal depression, anxiety and serious mental illness (SMI) in UK general practice and quantify impacts of socio...

Brain areas implicated in the stress response include the amygdala, hippocampus and prefrontal cortex. Neonatal stimulation of an animal by handling or by enhanced maternal care induces at adult age a decrease of the hypothalamo-pituitary adrenal (HPA) response to stressors, a decrease of anxiety in a novel environment, and neuroanatomical changes. In this present study we demonstrated that mat...

OBJECTIVE The objective of this study was to observe the effect of maternal deprivation on somatic growth of wistar rat pups viz. Body weight, nose-rump length, tail length and head length. MATERIALS AND METHOD 5 days old 50 rat pups were studied dividing equally into control and experimental groups. Experimental group (N=25) of rats were maternally deprived 1-4 hours twice daily till the wea...

A patient in her 20s was referred to us for psychological assessment due to her depression and suicide attempts. She mentioned being anorgasmic except when diapered and emphasized her erotic preference for diapers. Her childhood included maternal deprivation in an impecunious family headed by an irritable physically disabled father on social assistance. Given the maternal deprivation in childho...

Hypothalamic neuropeptide Y (NPY) activity is believed to play an important role in the response to food deprivation in adult rats. Little is known, however, about the role of the hypothalamic NPY system in the control of food intake in the preweanling rat. To address this issue, we examined the effect of deprivation on arcuate nucleus preproNPY expression in lean Zucker rat pups, using in situ...

Perturbations of the maternal environment involve an abnormal intrauterine milieu for the developing fetus. The altered fuel supply (depends on substrate availability, placental transport of nutrients and uteroplacental blood flow) from mother to fetus induces alterations in the development of the fetal endocrine pancreas and adaptations of the fetal metabolism to the altered intrauterine envir...