Background: Trial data often does not cover a sufficiently long period of time to truly capture time-toevent endpoints, however, Health Technology Assessment (HTA) bodies often require overall survival (OS) and progression-free survival (PFS) estimates. Often, significant survival effects are found beyond the time period observed in clinical trials, thus, extrapolation of trial results is requi...

A globally felt progressive idea for business world identified is entrepreneurship (Scott, 1986) creating diverse opportunities future potential performers (Mitra, 2002). Education of women have resulted in greater self-confidence and encouragement to serve discover new avenues. Women started realizing that the survival their families own lies only working side by with men (Marlow, Apart from m...

Joseph Conrad's Heart of Darkness portrays the inhabitants Congo from non-human perceptions. Charles Marlow’s observation and analysis citizens are based on prejudiced viewpoints pre-defined white archetypes. The chief motive Belgians was to justify native as ferocious collect ivory Congo. Natives did not recognize worth tusk while men ship it Europe brand ornamental articles. This representati...

We read with interest the report by Marlow et al on an infant with Marfan's syndrome and mitral valve dysfunction who died after acute illness with gross cardiac failure.' The authors stated that 'disease affecting the mitral valve is usually more benign than that of the aortic valve ....' This statement, however, may not be applicable to infants and young children with Marfan's syndrome. We ha...