A highly potent secondary metabolite producing actinomycetes strain is isolated from marine soil sediments of Visakhapatnam sea coast, Bay of Bengal. Over all ten strains are isolated from the collected soil sediments. Among the ten actinomycetes strains the broad spectrum strain RSPSN2 was selected for molecular characterization, antibiotic production and its purification. The nucleotide seque...

Antibiotic resistant pathogens pose an enormous threat to the treatment of various serious infections. To overcome this condition, a periodic replacement of the new and existing antibiotic is necessary. Antibiotics in combination with biosynthesized silver nanoparticles minimize the antibiotic doses to cure the dreaded diseases. In this study, Silver nanoparticles were bio-synthesized by extrac...

Marine Streptomyces are prolific producers of majority of bioactive secondary metabolites which are used in pharmaceutical industry as effective drugs against life threatening diseases. The cytotoxic activity of the pure compound 1, 2- benzene dicarboxylic acid, mono 2- ethylhexyl ester (DMEHE) from marine derived actinomycete Streptomyces sp. VITSJK8 was investigated against mouse embryonic fi...

Spithioneines A and B (1 and 2), two new bohemamine-type pyrrolizidine alkaloids possessing an unusual ergothioneine moiety, were isolated from a marine-derived Streptomyces spinoverrucosus. Their structures were elucidated by spectroscopic analysis, CD spectra, and chemical degradation and synthesis. Compounds 1 and 2 are rare natural products that incorporate the amino acid ergothioneine.

Abstract: Background: Actinomycetes are unique and ubiquitous organisms in nature historically holding first position as one of the major antibiotic producers. The aim study was screening pre-treatments soil, marine, mangrove samples for isolation producing actinomycetes. Materials Methods: were isolated from pre-treated using different media. They assessed antimicrobial activity by cross strea...

Three new polyketides, phaeochromycins F (1), G (2), H (3), were obtained from the culture broth of marine actinomycete strain Streptomyces sp. DSS-18. Their structures were established on the basis of detailed spectroscopic analyses, including 1D-, 2D-NMR and HR-ESI MS techniques.

Currently, corticosteroids are the most potent anti-inflammatory drugs on the market. Here, we announce the draft genome sequence of the marine-derived Streptomyces sp. strain CNQ431, which produces cytokine inhibitors, termed splenocins, which display potent suppression of cytokine production at a comparable level to that of corticosteroids. The genome is approximately 498,750 bp with 72.03% G...

Copyright: © 2013 Kadiri S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Isolation and Identification of A Novel Aporphine Alkaloid SSV, An Novel Antitumor Antibiotic from Fermented Broth of Marine A...