This article provides an overview about specifically modified Mannich reactions where the process involves an ortho-quinone methide (o-QM) intermediate. The reactions are classified on the basis of the o-QM source followed by the reactant, e.g., the dienophile partner in cycloaddition reactions (C=C or C=N dienophiles) or by the formation of multicomponent Mannich adducts. Due to the important ...

We report the development of direct catalytic, enantioselective, anti-selective Mannich-type reactions between unmodified ketones and alpha-imino esters under mild conditions. The reactions were performed using 5-10 mol % of (R)-3-pyrrolidinecarboxylic or (R)-beta-proline as catalyst in an environmentally benign solvent, 2-PrOH, at room temperature. The anti-Mannich products were obtained in go...

Non-coordinated hydroxymethylphosphines react readily with primary and secondary amines by the phosphorus Mannich reaction. To determine if this reactivity can be used to synthesize phosphine macrocycles, trans-Fe(DHMPE)(2)Cl(2) (DHMPE = 1,2-bis(dihydroxymethylphosphino)ethane) was prepared and reacted with various amines. However, no phosphorus Mannich reactivity was observed. In order to unde...

The condensation reactions between Gabapentin lactam and phenols have been carried out in the presence of formaldehyde for synthesis various mannich base series. To confirm formation these series newly prepared bases thus synthesized, characterization techniques used, such as, GC-MS, 1H-NMR, 13C-NMR FT-IR. Further their antibacterial antifungal activities against pathogenic bacteria evaluated. ...

Uncovering the value of waste materials is one keys to sustainability. In this current work, valorization chitosan was pursued fabricate a novel modified functional hydrogel using process-efficient protocol. The fabrication proceeds by one-pot and single-step C-Mannich condensation (3% w/v), glutaraldehyde (20 eq.), 4-hydroxycoumarin (40 eq.) at 22 °C in 3% v/v acetic acid. Mannich base (CS-MB)...

The asymmetric Mannich reaction ranks among the most potent enantioselective and diastereoselective C-C-bond forming reactions. In recent years, organocatalysed versions of asymmetric Mannich processes have been increasingly reported and used in a rapidly growing number of applications. This tutorial review provides an overview of the recent history of the asymmetric organocatalysed Mannich rea...