The world is endangered by the COVID‐19 pandemic caused SARS‐CoV‐2, people are dying in thousands every day, and without an actual treatment, it seems that bringing this global health problem to a quit impossible. Natural products have been constant use since ancient times proven time be effective. Medicinal plants from Indonesia may lead discovery of novel drugs. Mangosteen or Garcinia mangost...

As part of ongoing research on cancer chemopreventive agents from botanical dietary supplements, Garcinia mangostana L. (commonly known as mangosteen) was selected for detailed study. Repeated chromatography of a CH2Cl2-soluble extract of the pericarp led to the isolation of two new highly oxygenated prenylated xanthones, 8-hydroxycudraxanthone G (1) and mangostingone [7-methoxy-2-(3-methyl-2-b...

Five xanthone derivatives and one flavanol were isolated from the dichloromethane extract of Garcinia mangostana. Dichloromethane, ethyl acetate extract and the major xanthone (α-mangostin) were evaluated in vitro against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi and free trypomastigotes of T. brucei. The major consti...

A new prenylated xanthone, 1,6-dihydroxy-3,7-dimethoxy-2-(3,7-dimethyloct-2,6-dienyl) xanthone (3-O-methylcowaxanthone) (1), together with four known xanthones, cowaxanthone (2), 7-O-methylgarcinone (3), α-mangostin (4) and γ-mangostin (5) were isolated from the latex of Garcinia cowa. The structure of compound 1 was elucidated on the basis of spectroscopic data interpretation, including 1D and...

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis infection that attacks the lungs. a dangerous can cause death. In overcoming it, safe and effective treatment needed so this be cured. The purpose of study was to determine potential activity active compounds derived from xanthones contained in mangosteen rind as inhibitor protein with comparison compound Isoniazid. used...

Cyclodextrins (CDs) have been extensively utilized as host molecules to enhance the solubility, stability and bioavailability of hydrophobic drug molecules through the formation of inclusion complexes. It was previously reported that the use of co-solvents in such studies may result in ternary (host:guest:co-solvent) complex formation. The objective of this work was to investigate the effect of...

A phytochemical investigation of the acetone extract from the immature fruits of Garcinia cowa led to the isolation of two novel tetraoxygenated xanthones, garcicowanones A (1) and B (2), together with eight known tetraoxygeanted xanthones. Their structures were determined by spectroscopic analysis. All isolated compounds were evaluated for their antibacterial activity against Bacillus cereus T...

Sunscreen Activity of α -mangostin from the Pericarps Garcinia mangostana Liandhajani, Maria Immaculata Iwo, Sukrasno, Andreanus A. Soemardji, Muhammad Hanafi

A new coumarin, hoseimarin (1), together with four other xanthones, trapezifolizanthone (2), osajaxanthone (3), β-mangostin (4) and caloxanthone A (5), were isolated from the stem bark of Calophyllum hosei. The structures of these compounds were established by using spectroscopic analysis which included (1)H NMR, (13)C NMR, COSY, DEPT, HMQC and HMBC experiments.