Perichondrium/periosteum is involved in regulating long bone growth. Long bones grow faster after removal or circumferential division of periosteum. This can be countered by culturing them in conditioned medium from perichondrium/periosteum cells. Because both complete removal and circumferential division are effective, we hypothesized that perichondrium/periosteum cells require an intact envir...

Cigarette smoke is associated with delayed fracture healing, alterations in mineral content, and osteoporosis, however, its effects on osteoblastic differentiation of osteoprogenitor cells are not fully understood. In the present study, we examined the effects of cigarette smoke extract (CSE) on osteoblastic differentiation of cultured human periosteum-derived cells. We found that CSE inhibited...

Segmental mandibular defects are typically reconstructed with vascularized bone grafts. Free transfer grafts require microvascular anastomosis, which may be difficult in vessel-depleted necks and high-risk patients. We report a case of squamous cell carcinoma of the lower gingiva involving the mandibular bone. We performed a combination of frozen autograft and pectoralis major (PM) flap to reco...

Frenal attachments are thin folds of mucous membrane with enclosed muscle fibers that attach the lips to the alveolar mucosa and underlying periosteum. Most often, during the oral examination of the patient the dentist gives very little importance to the frenum. The frena may jeopardize the gingival health when they are attached too closely to the gingival margin, either due to interference in ...

Tendon transfers pptay an important role in reconstructive foot and ankle surgery. Multiple methods for fixation of tendon to bone are used including suture of tendon to periosteum, suture into bone troughs, suture anchors, and passage through bone tunnels. With the increasing populatity of hamstring tendon anterior cruciate ligament reconstructions has come new fixation technology. Soft-tissue...

Bone tissue engineering shows good prospects for mandibular reconstruction. In recent studies, prefabricated tissue-engineered bone (PTEB) by recombinant human bone morphogenetic proteins (rhBMPs) applied in vivo has found to be an effective alternative for autologous bone grafts. However, the optimal time to transfer PTEB for mandibular reconstruction is still not elucidated. Thus, here in an ...

Bone repair requires the mobilization of adult skeletal stem cells/progenitors to allow deposition of cartilage and bone at the injury site. These stem cells/progenitors are believed to come from multiple sources including the bone marrow and the periosteum. The goal of this study was to establish the cellular contributions of bone marrow and periosteum to bone healing in vivo and to assess the...

Bone formation in small deposits following the loss of part of the mandible has often been reported in the literature, but reports of complete bone regeneration extending over the entire anterior mandible from angle to angle is rare. Even rarer, are reports on the behaviour of such new bone in terms of facial development, over a long term and the effect of load carrying on it. Presented here is...

Introduction: Dogs have been used for ages in surgical research, drug testing and in researching dog's disorders that are similar to human diseases. [1] It has been used as a model for many human conditions as cardiovascular research, diabetes mellitus, ulcerative colitis, open-heart surgery, organ transplantation, pharmacology and toxicology. Dogs are "diphyodont" having two sets of teeth, "28...

PURPOSE A two stage approach of ridge splitting and lateral expansion in the mandible to achieve enough bone width for the purpose of dental implants is presented. MATERIALS AND METHODS A total of 13 consecutive patients with 16 long-span edentulous areas of the mandibular ridge were included in this study and 42 dental implants were inserted. Corticotomy of a rectangular buccal segment was c...