BACKGROUND Mycophenolic acid (MPA) is the first-line antimetabolic immunosuppressants used in solid organ transplantation. Here, in vivo expressions of the pharmacodynamic marker IMPDH mRNA were analyzed to investigate its usefulness in assessing drug effects. MATERIALS AND METHODS Six healthy male volunteers who had the same genotype for genes known to be associated with drug metabolism and ...

OBJECTIVES Whiplash injuries from vehicle collisions are common and costly. These injuries most frequently occur as a result of a rear impact and, compared to males, females have up to twice the risk of whiplash-associated disorders (WAD) resulting from vehicle crashes. The present study focuses on the differences in the dynamic response corridors of males and females in low-severity rear impac...

Objective: Some of the adverse effects of aspirin including peptic ulcers, gastrointestinal bleeding and aspirin resistance compelled researchers to find a suitable alternative with fewer adverse effects. In this clinical trial, we aimed to find the effective antiplatelet dose of garlic. Materials and Methods: This randomized controlled clinical trial (RCT) was conducted on 62 healthy volunteer...

PURPOSE We used functional MR imaging to compare hemispheric language dominance in healthy volunteers and in patients with epilepsy. METHODS We retrospectively reviewed the functional MR images of 23 healthy volunteers and 16 patients with epilepsy obtained by using an echo-planar technique designed for whole-brain imaging. The activation paradigm used was a silent word generation task. Hemis...