background: antibiotic therapies used in treatment of many diseases have adverse effects on fertility. this review analyzes previous comparative studies that surveyed the effects of two common groups of antibiotics on male fertility. objective: to evaluate histo-pathological effects of fluoroquinolones and aminoglycosides on sperm parameters and male reproductive tissue. materials and methods: ...

an important part of male infertility of unknown etiology may be attributed to various environmental and occupational exposures to toxic substances, such as lead. the reproductive effects of lead are complex and appear to involve multiple pathways, not all of which are fully understood. it is still unclear, for example, if male reproductive issues in lead-exposed persons are mostly related to t...

background: given the paucity of data on possible testis changes in opioid dependents, we sought to compare the testis volumes between a group of opium dependents and a group of healthy controls. objective: comparison of testis volume between opium dependents and healthy controls. materials and methods: this case-control study recruited 100 men with opium dependency (cases) and 100 healthy men ...

background and aims: quantum dots (qds), as colloidal nanocrystalline semiconductors, present qd wavelengths in terms of biomedical assays and imaging, though the high toxicity of their core demands to be taken into consideration. investigating this subject is taken into account as an important concept   concerning use of these nanoparticles in the medical applications. materials and methods: 1...

T he toxicity of lead has been known for millennia and has served as a template for toxicology studies. According to some 45 000 measurements in European industrial settings spanning smelters, battery manufacturing, and foundries, the average concentration of lead in blood steadily declined from 68 mg/dl in 1970 to 35 mg/dl in 1995. In parallel with this development the introduction of non-lead...

The aim of study was to investigate the toxic effect of triptolide fed in bait on reproduction of male house rat, Rattus rattus. Feeding of cereal based bait containing 0.2% triptolide to male R. rattus for 5 days in no-choice feeding test, leading to mean daily ingestion of 20.45 mg/kg bw of triptolide, was found effective in significantly (P ≤ 0.05) reducing sperm motility and viability in ca...

AIM The aim was to evaluate the effect of multiple oral administration of bisphenol A (BPA) for 28 days on seminal characteristic on mammal using Wistar rat as a model. MATERIALS AND METHODS Rats were randomly divided into five different groups having 6 male rats in each group. The doses chosen were 50, 200, and 600 mg/kg body weight for Groups III, IV and V, respectively, based on preliminar...

Gold nanoparticles have received wide interest in disease diagnosis and therapy, but one of the important issues is their toxicological effects in vivo. Sex differences in the toxicity of gold nanoparticles are not clear. In this work, body weight, organ weight, hematology, and biochemistry were used to evaluate sex differences in immune response and liver and kidney damage. Pathology was used ...

The fathead minnow (Pimephales promelas) is an OECD-proposed test species routinely used in reproductive toxicity trials with suspected endocrine-disrupting compounds (EDCs). The basic fecundity, endocrinology, and histopathology of reproductively active male and female fathead minnows has been well characterized, but there are few studies of the utility of male sperm concentration and motility...

Arsenic (As) is a ubiquitous environmental contaminant. Excess As exposure is considered one of the top health threats worldwide. As-induced Male reproductive toxicity is causing wide concern. The goal of this study is to determine whether subchronic As exposure inhibits Ddx3y expression, an Y-linked gene important in spermatogenesis and sperm maturation, and whether the inhibited expression of...