In this study, the effects of acetylsalicylic acid (ASA), the active agent in aspirin, and acetaldehyde (AcH), an intermediate metabolite in alcohol metabolism, on life span and some developmental characteristics of Drosophila melanogaster are investigated. Substance administration was done on adult Drosophila through feeding. The effects were investigated using both ASA and AcH individually (A...

The scientific debates on the future of human life span and its possible biological limits revealed a great need for direct identification of longevity boundaries, if they really exist. The key question posed in this study is as follows: how can we possibly determine the age when human longevity starts? To address this problem, we studied the familial transmission of human life span from parent...

BACKGROUND Little is known about the number or chromosomal location of genetic loci that might identify individuals destined to have a long life span. Analysis of gene/life span associations in mice, which are short-lived compared to humans, might provide guidance for an analysis of the genetic basis of life span in humans. METHODS A group of 144 genetically heterogeneous mice, produced by a ...

Age is a major factor explaining variation in life-history traits among individuals with typical patterns of increasing trait values early in life, maximum trait expression, and senescence. However, age-dependent variation in the expressions of sexually selected traits has received less attention, although such variation underpins differences in male competitive abilities and female preference,...

The extent to which inbreeding depression affects longevity and patterns of survivorship is an important issue from several research perspectives, including evolutionary biology, conservation biology, and the genetic analysis of quantitative traits. However, few previous inbreeding depression studies have considered longevity as a focal life-history trait. We maintained laboratory populations o...

Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. It is possible that the life-prolonging effects of calorie restriction are due to decreasing IGF-1 levels. A search of pharmacological modulators of insulin/IGF-1 signaling pathway (which mimetic effects of life span extending mutations or c...

Studies that have found a positive influence of moderate, nonexhaustive exercise on life expectancy contradict the rate-of-living theory, which predicts that high energy expenditure in exercising animals should shorten life. We investigated effects of exercise on energy metabolism and life span in male mice from lines that had been selectively bred for high voluntary wheel-running activity and ...

Background and aim: Cicatrical alopecia refers to lesions associated with permanent destruction of hair follicles. Several diseases such as folliculitis decalvans, lichenplanopilaris (LPP) and discoid lupus erythematosus (DLE) may result in cicatricial alopecia. Since cicatricial alopecia is scarring and affects both the appearance and psychosocial behaviours of the patients and also it c...

We evaluated the effect of various light/dark regimens on the survival, life span and tumorigenesis in rats. Two hundred eight male and 203 females LIO rats were subdivided into 4 groups and kept at various light/dark regimens: standard 12:12 light/dark (LD); natural lighting of the North-West of Russia (NL); constant light (LL), and constant darkness (DD) since the age of 25 days until natural...

We evaluated the effect of exposure to constant light started at the age of 1 month and at the age of 14 months on the survival, life span, tumorigenesis and age-related dynamics of antioxidant enzymes activity in various organs in comparison to the rats maintained at the standard (12:12 light/dark) light/dark regimen. We found that exposure to constant light started at the age of 1 month accel...