The present study was designed to evaluate the effect of ethanol on pituitary adenylate cyclase activating polypeptide (PACAP) and its typ I (PAC1) receptor expression in adult rat testes. Ethanol (3 g/kg i.p., 15% v/v in saline) was administrated to adult male rats for 10 days. Using northern blot analysis, the present study showed the reduction of PACAP mRNA levels in rat testes by ethanol ad...

introduction: previous studies have shown that ghrelin inhibits the activity of hypothalamus –pituitary – thyroid (h–p-t) axis. it is also proved that ghrelin increases appetite via agouti related protein and neuropeptide y pathway, decreases t3 & t4 secretion and inhibits serotonin release from hypothalamic synaptosomes. serotonin may interact with ghrelin in control of thyroid hormones secret...

Dementia is one of the most important problems nowadays. Aging is associated with learning and memory impairments. Diet rich in cholesterol has been shown to be detrimental to cognitive performance. This work was carried out to compare the effect of high cholesterol diet on the hippocampus of adult and aged male albino rats. Twenty adult and twenty aged male rats were used in this study. Accord...

Present study to investigate the effects of lindane in steroidogenesis and testis tissues of adult male albino rat. Adult male rats were orally administered with lindane at a dose of 5.0mg/kg body weight per day for 30 days, the rat were killed using anesthetic ether, plasma was collected and testis were removed histopathological studies. Male albino rats were treated with lindane, decreased th...

Early in ontogeny, young rats must be able to detect dangerous stimuli and to exhibit appropriate defensive behaviors. Different nuclei of the amygdala mediate unconditioned and conditioned fear responses to threat in adult rats. The aim of this study was to determine the role of the amygdala in unlearned fear behavior in young rats. When exposed to an unfamiliar adult male rat, preweaning rat ...

The estrogen receptor-alpha (ERalpha) knockout mouse (alphaERKO) lacks ERalpha throughout development; therefore, an adult model for the study of estrogen effects in male mice was recently developed using the antiestrogen ICI 182,780. However, differences between species have been noted during immunostaining for ERalpha in the male tract as well as in response to treatments with antiestrogens. ...

Background: Up until now, the effect of thyroid hormones on the male reproductive organ, after puberty, is not well understood. OBJECTIVES: In the present study, the morpho-histometrical effects of thyroid hormone deficiency on the adult-male rat reproductive organs were investigated. MATHODS: Thirty adult male rats were randomly divided into three groups (n=10): control, hypothyroid, and hypot...

background lithium is a drug for treatment of bipolar disorder by correcting mania and reducing depressive mood swings. objectives in this study, effects of lithium on volumetric parameters of cerebellum were investigated using stereological methods. materials and methods in this experimental study, 20 sexually mature wistar male rats were selected and divided in two groups randomly (n = 10). a...