much as the active and intelligent treatment adopted proved so utterly unavailing.?Ed.] Mr. V. T. was 42 years of age. On Sunday, 3rd March, he returned to Hazareebaugh from a long tour in the Tributary Mahals, where he had suffered much from " fever and bilious attacks." I learn from his journal that he was often ill for days together, yet he pushed on, determined to perform the duty fully ; a...

using mutation specific pcr assay and analysis of position 108 amino acid in dihydrofolate reductase-thymidilate synthase gene in 70 plasmodium falciparum isolates of malarial patients from southern areas of iran, showed 4 different situations: iwild type (108-ser) ii-mutant type (108-thr) iii-mutant type (108-asn) and iv-mixed wild and mutant type (108-ser+thr) with frequency of 58(82.8%), 2(2...

Macrophage-dependent killing of facultative intracellular bacteria was markedly impaired by overt erythrocytic Plasmodium yoelii or Plasmodium berghei infection of mice. P. yoelii infection was capable of ablating not only the macrophage microbicidal capacity of "normal" animals but also the bactericidal capacities of "activated" macrophages. The uptake by spleen and liver of an intravenous cha...

BACKGROUND Hyperparasitaemia is a feature of childhood severe malaria but there is little information on the risk factors for hyperparasitaemia in malarious children METHODS The risk factors associated with Plasmodium falciparum hyperparasitaemia, defined as asexual parasitaemia > 250,000/μl, at presentation were evaluated in 3338 malarious children enrolled prospectively between 2008 and 201...

Malaria may be encountered in parts of South Africa not known to have malaria, in ways not typical of how it is usually transmitted or acquired. In this issue of SAMJ two articles discuss two clinical forms of malaria in non-endemic areas, imported malaria and odyssean malaria. Imported malaria is defined as malaria presenting in a country other than that in which it was acquired, while odyssea...

background: point mutations in the genes, pfcrt and pfdhfr , have been identified elsewhere as strongly associated with re­sistance to chloroquine (cq) and pyrimethamine, respectively.  methods: using a restriction digestion method, we report the frequency of two important mutations, t76 and asn108, re­spon­sible for conferring resistance to chloroquine and pyrimethamine, respectively, in patie...

a total of 3204 abo and rh blood groups were investigated in larestan and lamerd populations, in fars province, in iran. the frequency of the a gene ranged from 16.54% to 21.96, the b gene from 15.85 to 27.77% and that of the d gene from 21.49 to 33.01% ; compared with the gene frequencies of 20.97% for the b and 28.50% for the d in the general population. it seemed that the two populations stu...