نتایج جستجو برای: magnetization transfer ratio mtr

تعداد نتایج: 795318  

Journal: :The Journal of neuropsychiatry and clinical neurosciences 2002
Paul A M Hofman Frans R J Verhey Jan T Wilmink Nico Rozendaal Jelle Jolles

Postconcussional disorder after a relatively mild head injury is common. Although a partial organic etiology is presumed, little imaging evidence exists for this assumption. In this study, patients with mild to moderate brain injury (median Glasgow Coma Scale score of 14) had more parenchymal brain lesions than control subjects (P=0.02). Additionally, the authors investigated the potential of q...

2009
S. Volz U. Nöth A. Rotarska-Jagiela R. Deichmann

Introduction Magnetization Transfer (MT) imaging is of increasing interest in neuroimaging, yielding important information, e.g. about myelin integrity in the central nervous system [1, 2]. However, a quantitative analysis of the MT ratio (MTR) is affected by several problems, especially at high field strengths: B1 inhomogeneities influence the MT saturation angle, biasing MTR values. High spec...

Journal: :AJNR. American journal of neuroradiology 1998
M D Phillips R I Grossman Y Miki L Wei D L Kolson M A van Buchem M Polansky J C McGowan J K Udupa

PURPOSE The purpose of this study was twofold: first, to compare two different measures of lesion burden in patients with multiple sclerosis (MS), the magnetization transfer ratio (MTR) histogram and T2 lesion volume; and, second, to investigate the relationship between lesion burden and atrophy in patients with MS. METHODS Thirty patients with MS were examined with MR imaging, including fast...

Journal: :AJNR. American journal of neuroradiology 2002
Yulin Ge Robert I Grossman James S Babb Marcie L Rabin Lois J Mannon Dennis L Kolson

BACKGROUND AND PURPOSE The magnetization transfer ratio (MTR) is a sensitive and quantitative identifier of underlying structural changes in the brain. We quantitatively evaluated age- and sex-related MTR changes in global gray matter (GM) and global white matter (WM) in healthy adults. METHODS Fifty-two healthy volunteers (21 men, 31 women) aged 20-86 years underwent dual-echo fast spin-echo...

2014
R.D. Newbould R. Nicholas C.L. Thomas R. Quest J.S.Z. Lee L. Honeyfield A. Colasanti O. Malik M. Mattoscio P.M. Matthews M.P. Sormani A.D. Waldman P.A. Muraro

BACKGROUND Multiple sclerosis (MS) is a heterogeneous disorder with a progressive course that is difficult to predict on a case-by-case basis. Natural history studies of MS have demonstrated that age influences clinical progression independent of disease duration. OBJECTIVE To determine whether age would be associated with greater CNS injury as detected by magnetization transfer MRI. MATERI...

Journal: :AJNR. American journal of neuroradiology 2013
R Wiest Y Burren M Hauf G Schroth J Pruessner M Zbinden K Cattapan-Ludewig C Kiefer

BACKGROUND AND PURPOSE Early stratification of degenerative processes is a prerequisite to warrant therapeutic options in prodromal Alzheimer disease. Our aim was to investigate differences in cerebral macromolecular tissue composition between patients with AD, mild cognitive impairment, and age- and sex-matched healthy controls by using model-based magnetization transfer with a binary spin-bat...

Journal: :AJNR. American journal of neuroradiology 2003
Yulin Ge Robert I Grossman James S Babb Juan He Lois J Mannon

BACKGROUND AND PURPOSE In contrast to "normal-appearing" white matter (NAWM) in patients with multiple sclerosis (MS), there are subtle, abnormal and diffuse signal intensity changes often seen on T2-weighted MR images, which we have referred to as "dirty-appearing" white matter (DAWM). These areas of DAWM have slightly higher signal intensity than that of NAWM, but lower than that of lesion pl...

Journal: :NeuroImage 2014
Deborah H. Schwartz Erin W. Dickie Melissa M. Pangelinan Gabriel Leonard Michel Perron G. Bruce Pike Louis Richer Suzanne Veillette Zdenka Pausova Tomás Paus

Obesity, a major risk factor for cardiometabolic disease, is associated with variations in a number of structural properties in the adult brain, as assessed with magnetic resonance imaging (MRI). In this study, we investigated the cross-sectional relationship between visceral fat (VF), total body fat (TBF) and three MRI parameters in the brains of typically developing adolescents: (i) T1-weight...

2017
Florian Borsodi Valeriu Culea Christian Langkammer Michael Khalil Lukas Pirpamer Stefan Quasthoff Christian Enzinger Reinhold Schmidt Franz Fazekas Stefan Ropele

Several quantitative magnetic resonance imaging (MRI) techniques have been proposed to investigate microstructural tissue changes in amyotrophic lateral sclerosis (ALS) including diffusion tensor imaging (DTI), magnetization transfer imaging, and R2* mapping. Here, in this study, we compared these techniques with regard to their capability for detecting ALS related white matter (WM) changes in ...

2013
Fei Du Dost Öngür

In this manuscript we present novel MRI approaches to dissecting axon vs. myelin abnormalities in psychiatric disorders. Existing DTI approaches are not able to provide specific information on these subcellular elements but novel approaches are beginning to do so. We review two approaches (magnetization transfer ratio-MTR; and diffusion tensor spectroscopy-DTS) and the theoretical framework for...

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