BACKGROUND The aim of this study was to investigate the use of prophylactic magnesium sulphate and amiodarone in treating arrhythmias that may occur following coronary bypass grafting operations. METHODS The study population consisted of 192 consecutive patients who were undergoing coronary artery bypass grafting (CABG). Sixty-four patients were given 3 g of magnesium sulphate (MgSO4) [20 ml ...

BACKGROUND Adequate analgesia following caesarean section decreases morbidity, hastens ambulation, improves patient outcome and facilitates care of the newborn. Intrathecal magnesium, an NMDA antagonist, has been shown to prolong analgesia without significant side effects in healthy parturients. We therefore studied the effect of adding intrathecal magnesium sulphate to bupivacaine-fentanyl spi...

BACKGROUND AND OBJECTIVES To assess the potential neurotoxic effects at the ultrastructural level of magnesium sulfate administered intrathecally as a single or multi-dose. METHODS Our study was conducted with 24 Sprague-Dawley rats that weighed 250-300 g. After a 4-hour fast, the rats were given 10 mg.kg(-1) xylazine chloride intraperitoneal and then randomly allocated into three groups. Gro...

OBJECTIVE To study the role of preoperative intravenous magnesium sulphate in decreasing post-cesarean pain and opioid requirement during first 24hrs. MATERIALS AND METHODS In a double blind randomized clinical trial, prior to induction of general anesthesia, fifty elective cesarean candidates were randomly assigned to one of the two groups of placebo or magnesium sulfate. After surgery visua...

✔ Objective: It has been shown that excess amount of glutamate released after primary neuronal injury by head trauma causes secondary injuries in the adult brain. Aiming to prevent this secondary injury a wide range of N-Methyl-D-aspartate receptor antagonist drugs have been investigated in experimental studies. Magnesium sulphate and memantine are pharmacological agents widely used clinically ...

BACKGROUND Antenatal magnesium sulphate, widely used in obstetrics to improve maternal and infant outcomes, may be associated with adverse effects for the mother sufficient for treatment cessation. This systematic review aimed to quantify maternal adverse effects attributed to treatment, assess how adverse effects vary according to different regimens, and explore women's experiences with this t...

Although it has been repeatedly established both in man and in animal experiments that magnesium has a depressant action on the heart, there is no general agreement about the mechanism of this action, and there are few reports dealing directly with the clinical application of its cardio-inhibitory properties. Zwillinger (1935) studied the effect of magnesium sulphate on paroxysmal tachycardia, ...

A large number of eclamptic patients with consistent rise as winter approaches attend the Obstetric Department of Janakpur Zonal Hospital (JZH). Magnesium sulphate is used for the treatment of all patients of eclampsia was found to have better prognosis. Besides this, mode of delivery has been influenced by control of fits and fetal maturity. Hence we set forth to determine the demographic char...

Background Pre-eclampsia and the subsequent eclampsia account for a common cause of maternal mortality worldwide and efforts aimed at reducing its menace are vital. Objective To estimate the serum magnesium levels in pre-eclampsia and eclampsia and to study the effect of using different regimens of magnesium sulphate. Methods 70 cases of pre-eclampsia and eclampsia and 35 normal pregnant women ...

INTRODUCTION Patients with phaeochromocytoma have haemodynamic instability during adrenalectomy. CLINICAL PICTURE A case showing major swings of blood pressure during tumour handling. TREATMENT Magnesium sulphate infusion alone failed to prevent severe hypertension. OUTCOME The patient had to be given phentolamine and sodium nitroprusside to control the severe hypertension. CONCLUSION T...