1512 normal enzyme. Then, they replaced the oxygen in question with a sulfur atom. The reaction didn’t work as well because, by the rules of chemistry, sulfur doesn’t like to bind to magnesium. But sulfur does like manganese and cadmium ions. So they replaced the magnesium with one of these other metal ions and measured the reaction. The researchers saw that these other metal ions restored (or ...

Magnesium sulfate is widely used in obstetrics and is drug of choice in two important complications of pregnancy, preeclampsia and preterm labor. The antagonistic effects of magnesium sulfate on calcium ion and on platelet aggregation may lead to changes in bleeding time. This study was conducted to evaluate the effect of magnesium sulfate on bleeding time in women with threatened preterm labor...

Magnesium is an important cofactor for many biological processes, such as protein synthesis, nucleic acid stability, or neuromuscular excitability. Extracellular magnesium concentration is tightly regulated by the extent of intestinal absorption and renal excretion. Despite the critical role of magnesium handling, the exact mechanisms mediating transepithelial transport remained obscure. In the...

Thirty-six crossbred gilts 10 months of age were bred and assigned to dietary magnesium levels of 400 or 900 ppm. At parturit ion the levels were modified to 150 and 650 ppm. During lactation phosphorus levels of .30 or .54% were fed within each magnesium level. Magnesium levels did not influence the number or weight of pigs at birth or weaning. Sows fed the high level of magnesium (650 ppm) ma...

Rechargeable Magnesium Batteries In article number 2300682, Zhenyou Li, Zhirong Zhao-Karger, and co-workers discuss the recent developments in cathode materials for rechargeable magnesium batteries with a particular focus on magnesium-ion diffusion interfacial processes. The remaining challenges, as well promising strategies towards fast electrochemical kinetics are also discussed.

Solid-state magnesium ion conductors with exceptionally high ionic conductivity at low temperatures, 5 × 10-8 Scm-1 at 30 °C and 6 × 10-5 Scm-1 at 70 °C, are prepared by mechanochemical reaction of magnesium borohydride and ethylenediamine. The coordination complexes are crystalline, support cycling in a potential window of 1.2 V, and allow magnesium plating/stripping. While the electrochemical...

Recent data suggests that the glutamatergic system is involved in the pathophysiology and treatment of major depressive disorder (MDD) and that the N-methyl-D-aspartate (NMDA) receptor is a potential target for antidepressant drugs. The magnesium ion blocks the ion channel of the NMDA receptor and prevents its excessive activation. Some preclinical and clinical evidence suggests also that magne...

Magnesium is necessary for the presynaptic release of acetylcholine from nerve endings and may produce effects similar to calciumentry-blocking drugs [1]. With the discovery of the N-methylD-aspartate (NMDA) receptor and its links to nociceptive pain transmission and central sensitization, there has been renewed interest in utilizing noncompetitive NMDA receptor antagonists, as potential antihy...

Isolated mammalian metaphase chromosomes suspended in ion-free or 10d3 YN&l solution undergo an irreversible, pH-dependent structural change, as reflected by electrometric titrations, pH-stat experiments and measurements of circular dichroism spectra. Unmasking of titratable groups with pK’s lower than the isoionic pH of chromosomes in ion-free water, pH 66, accompanies the change in conformati...

Addition of magnesium phosphate [Mg3(PO4)2 x 8H2O] to a complex medium or to an ammonium ion-containing, chemically defined medium stimulated leucomycin production by Streptomyces kitasatoensis. Ammonium ions in high concentrations inhibited leucomycin production, but their limitation by magnesium phosphate led to the high production of the antibiotic.