A synthetic pathway is introduced to construct fluorescent composite macromolecules with supramolecular assemblies as structural units. The supramolecular assembly that contains polymerizable groups is used as a starting "monomer." The supramolecular assembly is composed of nanoparticle core of II - IV group semiconductor and organic ammonium shell. Polymerization of the assemblies yields solub...

Introduction: A recent study suggested that water macromolecule exchange (WME) processes can contribute to the in vivo gray matter (GM) and white matter (WM) contrast in high field phase imaging [1]. Due to the complex nature of macromolecule-water interaction, bovine serum albumin (BSA) was used as a model system to demonstrate this effect. It is assumed that the WME interaction depends on the...

The mechanism of threshold elongation (overstretching) of DNA macromolecules under the action of external force is studied within the framework of phenomenological approach. When considering the task it is taken into account that double-stranded DNA is a polymorphic macromolecule with a set of metastable states. Accordingly to proposed mechanism, DNA threshold elongation can take place as a coo...

The kinetics of the flux of a charged macromolecular solution through an environment of changing geometry with wide and constricted regions is investigated analytically. A model device consisting of alternating deep and shallow slits known as an "entropic trap" is used to represent the environment. The flux is supported by the external electrostatic field. The "wormlike chain" model is used for...

To understand the mechanism of TATA-box conformational transformations we model structure mobility and find the types of conformational excitations of DNA macromolecule in heteronomous conformation. We have constructed the twocomponent model for describing DNA conformational transformation with simultaneous transitions in the furanos rings of the monomer link. Internal component describes the c...

Using molecular dynamics simulations in an explicit aqueous solvent, we examine the binding of fluoride versus iodide to a spherical macromolecule with both hydrophobic and positively charged patches. Rationalizing our observations, we divide the ion association interaction into two mechanisms: (1) poorly solvated iodide ions are attracted to hydrophobic surface patches, while (2) the strongly ...

Macromolecule Dynamics: from a Coarse Grain Approach to Continuum Modeling