ABTRACT The macrocyclic ligands are synthesized by taking etylenediamine and semicarbazide hydrochloride with acetyl acetone respectively in ethanolic medium further their Oxovanadium complexes were synthesized by taking metal salt of type VO (acac)2. Ligands and complexes have been analysed for their physical properties with the help of melting point, molecular weight, conductance , TLC determ...

The synthesis and photophysical properties of butadiyne-linked chlorophyll and porphyrin dimers in toluene solution and in several self-assembled prismatic structures are described. The butadiyne linkage between the 20-positions of the macrocycles results in new electronic transitions polarized along the long axes of the dimers. These transitions greatly increase the ability of these dimers to ...

A group of researchers from NRCN, Ben Gurion University and the CEA shows that cyclen-derived, hard-bonding ligands facilitate formation tetravalent cerium cations bearing oxo/hydroxo clusters in aqueous solutions. The eventually decompose to form thermodynamically favoured “in-cage” cerric macrocyclic complex. More information can be found Research Article by S. Pevzner, E. Maimon, Y. Ben-Eliy...

Macrocyclic ligands 1 and 2 containing two positively charged phenanthridinium units and aminobisacetylenic bridges, exhibit significantly higher affinity toward single-stranded rather than double-stranded polynucleotides. The ligands bis-intercalate into the former and show non-intercalative interactions with the latter type of nucleic acids. Both ligands differentiate AMP from the GMP or UMP ...

Four copper(II) complexes have been prepared using macrocyclic ligands. The macrocyclic ligands have been synthesized by the condensation reaction of diethyl phthalate with Schiff bases derived from o-phenylene diamine and Knoevenagel condensed β-ketoanilides (obtained by the condensation of acetoacetanilide and substituted benzaldehydes). The ligands and copper complexes have been characterize...

We introduce the ForceGen method for 3D structure generation and conformer elaboration of drug-like small molecules. ForceGen is novel, avoiding use of distance geometry, molecular templates, or simulation-oriented stochastic sampling. The method is primarily driven by the molecular force field, implemented using an extension of MMFF94s and a partial charge estimator based on electronegativity-...

Glycolytic interconversion of phosphoglycerate isomers is catalysed in numerous pathogenic microorganisms by a cofactor-independent mutase (iPGM) structurally distinct from the mammalian cofactor-dependent (dPGM) isozyme. The iPGM active site dynamically assembles through substrate-triggered movement of phosphatase and transferase domains creating a solvent inaccessible cavity. Here we identify...

Synthetic superoxide dismutase mimetics have emerged as a potential novel class of drugs for the treatment of oxidative stress related diseases. Among these agents, metal complexes with macrocyclic ligands constitute an important group. In this work we synthesized five macrocyclic copper(II) complexes and evaluated their ability to scavenge the superoxide anions generated by the xanthine-xanthi...

Substitution of the amide donors in open-chain {2N(oxime), 2N(amide)} ligands by hydrazide donors gives new pseudo-macrocyclic copper complexes that show a significant decrease of the Cu(3+/2+) redox potentials in both mono- and polynuclear systems, thus demonstrating a pronounced capacity of such ligand systems to efficiently stabilize the trivalent copper.

Several unusual complexes of ytterbium(ii) stabilised by coordination to mixed O4X2-donor macrocyclic ligands (X = O, NH, S or Se) are described. Distorted 8-coordination is evident from the crystal structure of the neutral [YbI2([18]aneO4Se2)], forming the first reported example of Yb(ii)-selenoether coordination.