TALE (transcription activator-like effector) proteins can be tailored to bind to any DNA sequence of choice and thus are of immense utility for genome editing and the specific delivery of transcription activators. However, to perform these functions, they need to occupy their sites in chromatin. In the present study, we have systematically assessed TALE binding to chromatin substrates and find ...

“thousand and one night” –with 251 narratives- is the best example of distinct storytelling in indian and iranian cultures. perhaps, it is the most voluminous story collection which has so far attracted researchers and theorist of narratology. narratology is a dynamic branch of literary theory. its final goal is discovering universal pattern of narrative. narrative is a closed chain of ev...

The ability to conditionally rewire pathways in human cells holds great therapeutic potential. Transcription activator-like effectors (TALEs) are a class of naturally occurring specific DNA binding proteins that can be used to introduce targeted genome modifications or control gene expression. Here we present TALE hybrids engineered to respond to endogenous signals and capable of controlling tr...

Designer transcription-activator like effectors (TALEs) is a promising technology and made it possible to edit genomes with higher specificity. Such specific engineering and gene regulation technologies are also being developed using RNA-binding proteins like PUFs and PPRs. The main feature of TALEs, PUFs and PPRs is their repetitive DNA/RNA-binding domains which have single nucleotide binding ...

In Japan, most of children haven’t read children’s story (Fairy tales or tales of old Japan) because the high technology video games are more exciting than most of picture books. But they must be effective to bring up the children’s cultivation of aesthetic sensitivity. And we have heard from teachers of elementary schools that most of themes of computer education in school are the operation of...

Xanthomonas TALE transcriptional activators act as virulence or avirulence factors by activating host disease susceptibility or resistance genes. Their specificity is determined by a tandem repeat domain. Some Xanthomonas pathogens contain 10-30 TALEs per strain. Although TALEs play critical roles in pathogenesis, their studies have so far been limited to a few examples, due to their highly rep...

In this paper, we present the digitization and annotation of a tales corpus which is to our knowledge the only French tales corpus available and classified according to the Aarne&Thompson classification composed of historical texts (with old French parts). We first studied whether the pre-processing tools, namely OCR and PoS-tagging, have good enough accuracies to allow automatic analysis. We a...

In this paper we argue that digital games have come to fill the cultural niche traditionally occupied by fairy tales, and that they are ideally suited to realize some of the unique characteristics of this genre of folklore and literature. One of the most influential authors of fantasy narrative, J.R.R. Tolkien, wrote extensively about fairy tales, authored fairy tales and considered his great e...

Transcription factors (TFs) act withinwider regulatory networks to control cell identity and fate. Numerous TFs, including Scl (Tal1) and PU.1 (Spi1), are known regulators of developmental and adult haematopoiesis, but how they act within wider TF networks is still poorly understood. Transcription activator-like effectors (TALEs) are a novelclassofgenetic toolbasedon themodularDNA-bindingdomain...

The e-book industry is reshaping the norm of traditional book publishing and most publishing houses are concentrating their efforts in digital, in order to satisfy new market needs and capture significant market share. Currently, one of out of five e-books sold, are children-related and overall, the e-book industry is projected to be valued at $18.9 billion by 2018. Nevertheless, the increased ...