Walking being the oldest form of urban transport, and until the advent of major transformationsin transport technology in the nineteenth century, most cities were structured in ways that supported walkability.Today, there is a change in transportation which emphasizes, the traditional pedestrian paths which are increasinglybecoming non-regulated spaces when compared to the urban spaces for auto...

Cell shape in most eubacteria is maintained by a tough external peptidoglycan cell wall. Recently, cell shape determining proteins of the MreB family were shown to form helical, actin-like cables in the cell. We used a fluorescent derivative of the antibiotic vancomycin as a probe for nascent peptidoglycan synthesis in unfixed cells of various Gram-positive bacteria. In the rod-shaped bacterium...

Cold-induced sweetening (CIS) in potato is detrimental to the quality of processed products. Conversion of starch to reducing sugars (RS) by amylases is considered one of the main pathways in CIS but is not well studied. The amylase genes StAmy23, StBAM1, and StBAM9 were studied for their functions in potato CIS. StAmy23 is localized in the cytoplasm, whereas StBAM1 and StBAM9 are targeted to t...

The MAP kinase-interacting kinases (MNK1 and MNK2) are non-essential enzymes which are activated by MAP kinases. They are implicated in controlling protein synthesis. Here we show that mice in which the expression of either MNK1 or MNK2 has been knocked out (KO) are protected against adverse effects of high-fat feeding, and in distinct ways. High-fat diet (HFD)-fed MNK2-KO show less weight gain...

We consider the tilings by translation of a single polyomino or tile on the square grid Z. It is well-known that there are two regular tilings of the plane, namely, parallelogram and hexagonal tilings. Although there exist tiles admitting an arbitrary number of distinct hexagon tilings, it has been conjectured that no polyomino admits more than two distinct parallogram tilings. In this paper, w...

MDM2 and MDMX are the chief negative regulators of the tumor-suppressor protein p53 and are essential for maintaining homeostasis within the cell. In response to genotoxic stress and also in several cancer types, MDM2 and MDMX are alternatively spliced. The splice variants MDM2-ALT1 and MDMX-ALT2 lack the p53-binding domain and are incapable of negatively regulating p53. However, they retain th...

It has been proved that, among the polyominoes that tile the plane by translation, the so-called squares tile the plane in at most two distinct ways. In this paper, we focus on double squares, that is, the polyominoes that tile the plane in exactly two distinct ways. Our approach is based on solving equations on words, which allows to exhibit properties about their shape. Moreover, we describe ...