Efavirenz (Sustiva) is a potent and specific inhibitor of the HIV-1 reverse transcriptase and is approved for the treatment of HIV infection. The metabolism of efavirenz in different species has been described previously. Efavirenz is primarily metabolized in rats to the glucuronide conjugate of 8-OH efavirenz. Electrospray ionization-liquid chromatography/mass spectrometry analyses of bile sam...

INTRODUCTION The electrophysiological responses obtained with the complex auditory brainstem response (cABR) provide objective measures of subcortical processing of speech and other complex stimuli. The cABR has also been used to verify the plasticity in the auditory pathway in the subcortical regions. OBJECTIVE To compare the results of cABR obtained in children using hearing aids before and...

in order to study the effects of on-farm seed priming and sowing date on germination percentage, germination speed, and some growth indices of three soybean cultivars, a field experiment was carried out in three replications using a split plot factorial in a randomized complete block design. main plots were representative of two sowing date (5th and 21th of may), while subplots included combina...

rootstock and cultivar selection is the most critical decision at the time of an apple orchard establishment. tree size, yield and fruit quality are affected by roostock and cultivar. non-sufficient study of rootstocks and cultivars effects on mentioned traits will lead to incorrect result or failure in orchard managing. in this study the effects of three vegetative rootstocks (mm106, mm111 and...

It has been shown that induced molting by complete feed withdrawal increases Salmonella horizontal transfer in laying hens and contamination in eggs. Zinc-containing diets have been used as an alternative means to induce molt in laying as a management while avoiding feed withdrawal. It is not known if the zinc in these molt diets would inhibit Salmonella spp. growth and therefore potentially mi...

The effects of different water stress (control, medium, and severe) on some morphological, physiological, and biochemical characteristics and bud success of M9 apple and MA quince rootstocks were determined. The results showed that water stress significantly affected most morphological, physiological, and biochemical characteristics as well as budding success on the both rootstocks. The increas...

Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an abundant nuclear protein that plays an important role in pre-mRNA processing and mRNA export from the nucleus. A1 shuttles rapidly between the nucleus and the cytoplasm, and a 38-amino acid domain, M9, serves as the bidirectional transport signal of A1. Recently, a 90-kD protein, transportin, was identified as the mediator of A1 nuclear i...