A series of Antibody Recruiting Glycodendrimer (ARG) was screened against the melanoma cell line M21. We identified lead ARGs that promote up to 57% selective cytotoxicity in presence human serum as unique source immunity effectors.

The efficient market hypothesis based primarily on the statistical principle of Bayesian inference has been proved to be only a special-case scenario. The generalized financial market, modeled as a binary, stochastic system capable of attaining one of two possible states (High  1, Low  0) with finite probabilities, is shown to reach efficient equilibrium with p . M = p if and only if the tran...

An (n, r)-arc is a set of n points of a projective plane such that some r, but no r + 1 of them, are collinear. The maximum size of an (n, r)-arc in PG(2, q) is denoted by mr(2, q). Using some good blocking sets in PG(2, 23) we establish that m22(2, 23) ≥ 484, m21(2, 23) ≥ 461, m20(2, 23) ≥ 437, m19(2, 23) ≥ 411, m18(2, 23) ≥ 385 and m17(2, 23) ≥ 360.

The observation of atmospheric neutrinos (See, e.g., Ref.) and solar neutrinos (See, e.g., Ref.) gives the information on the mass squared differences and the mixings, which can be written in the three flavor framework of neutrino oscillations as (|∆m32|, θ23) and (∆m21, θ12), where I have adopted the standard parametrization 3 for the 3 × 3 MNSP 5,6 matrix. On the other hand, the CHOOZ result ...

We report measurements of thermal self-locking of a Fabry–Perot cavity containing a potassium niobate (KNbO3) crystal. We develop a method to determine linear and nonlinear optical absorption coefficients in intracavity crystals by detailed analysis of the transmission line shapes. These line shapes are typical of optical bistability in thermally loaded cavities. For our crystal we determine th...

We report here our studies on the ¡nhibitionaleffect of 45°Cheat shock on transcriptions! and translational activity and their subsequent recovery at 37°Cin Rat-1 cells, thermotolerant Rat-1 cells ('IT Rat-1), and Rat-1 cells transfected with human hsp70 gene (IIR24, M21). Specifically, we ask whether overexpression of hspTOprotects cells from heat-induced inhibition in RNA and protein synth...

Surfactant protein B (SP-B) is a 79-residue essential component of lung surfactant, the film of lipid and protein lining the alveoli, and is the subject of great interest for its role in lung surfactant replacement therapies. Here we report circular dichroism results and the solution NMR structure of SP-B(11-25) (CRALIKRIQAMIPKG) dissolved in CD(3)OH at 5 degrees C. This is the first report of ...

The trisomy of human chromosome 21 (Hsa21), which causes Down syndrome (DS), is the most common viable human aneuploidy. In contrast to trisomy, the complete monosomy (M21) of Hsa21 is lethal, and only partial monosomy or mosaic monosomy of Hsa21 is seen. Both conditions lead to variable physiological abnormalities with constant intellectual disability, locomotor deficits, and altered muscle to...

Although nanomaterials have been widely investigated for drug delivery, imaging and immunotherapy, their potential roles in triggering innate cellular immune responses while simultaneously serving as imaging enhancer remain unexplored. In this work, gold nanoparticles (GNPs) conjugated to the tumor-targeting anti-GD2 antibody hu14.18K322A, namely HGNPs, were designed and synthesized to specific...

We report here our studies on the inhibitional effect of 45 degrees C heat shock on transcriptional and translational activity and their subsequent recovery at 37 degrees C in Rat-1 cells, thermotolerant Rat-1 cells (TT Rat-1), and Rat-1 cells transfected with human hsp70 gene (HR24, M21). Specifically, we ask whether overexpression of hsp70 protects cells from heat-induced inhibition in RNA an...