OBJECTIVE small size at birth has been associated with increased risk of type 2 diabetes. Our aim was to evaluate how risk of diabetes associated with low birth weight is affected by accumulation of body mass from childhood to adulthood. RESEARCH DESIGN AND METHODS Subjects from the 1958 British birth cohort (born 3-9 March 1958) have been followed regularly since birth. In the survey at 41 y...

Abstract Background Primary progressive aphasias (PPAs) are a group of neurodegenerative disorders characterized by an insidious and language impairment. Clinical expression underlying pathology remain highly heterogeneous. To date, there is lack knowledge on the natural history each three main variants, particularly mortality. Moreover, advanced stages end life issues rarely discussed with car...

OBJECTIVES Demographic and presentation profile of patients using an innovative mobile outreach clinic compared with mainstream practice. DESIGN Retrospective cohort study. SETTING Primary care mobile street health clinic and mainstream practice in Western Australia. PARTICIPANTS 2587 street health and 4583 mainstream patients. MAIN OUTCOME MEASURES Prevalence and patterns of chronic di...

Animal models indicate that exposure to choline in utero improves visual memory through cholinergic transmission and/or epigenetic mechanisms. Among 895 mothers in Project Viva (eastern Massachusetts, 1999-2002 to 2008-2011), we estimated the associations between intakes of choline, vitamin B12, betaine, and folate during the first and second trimesters of pregnancy and offspring visual memory ...

Most current references recommend divided doses of prednisolone for the initial treatment of idiopathic minimal change nephrotic syndrome in children, with relapse occuring in the majority of them, but there is little experience concerning single-dose prednisolone therapy, especially considering the relapse rate. In this prospective study on 36 consecutive children with primary nephrotic s...

Recent studies reported different ages for peak freestyle swimming performances for 50 m and 1,500 m. The aims of the present study were (i) to determine the age of peak freestyle swimming speed for distances including 50 m, 100 m, 200 m, 400 m, 800 m, and 1,500 m and to (ii) analyze the sex difference in peak freestyle swimming speed for all distances between 50 m and 1,500 m for elite female ...

PURPOSE To investigate response to sequential treatment schedules and risk of development of refractory epilepsy in childhood. METHODS All children younger than 14 years with two or more unprovoked seizures seen at our hospital between 1994 and 2004 were included and prospectively followed. "Seizure control" was defined as a 2-year seizure-free interval without further recurrences except thos...

BACKGROUND The objective of this study was to determine the long-term outcome of patients after percutaneous balloon pulmonary valvuloplasty (BPV) treatment of congenital pulmonary valve stenosis. METHODS AND RESULTS This study represents a case series with duration (mean +/- SD) of follow-up of 4.6 +/- 1.9 years. Forty-six patients with a median age of 4.6 years (range, 3 months to 56 years)...

Purpose: To describe the clinical findings and treatment modalities of persistent hypotony following primary trabeculectomy with mitomycin C. Methods: We retrospectively analyzed 9 eyes with persistent hypotony, which was defined as intraocular pressure less than or equal to 5 mmHg for more than 2 months. Results: Mean hypotony duration was 7.4 months (standard deviation (SD) ± 6.7 months, rang...