We analyzed the G-actin-regulated transcriptome by gene expression analysis using previously characterized actin-binding drugs. We found many known MAL/MRTF-dependent target genes of serum response factor (SRF), as well as additional directly regulated genes. Surprisingly, several putative antiproliferative target genes were identified, including mig6/errfi-1, a negative regulator of the EGFR f...

SIR, We were interested to read the recently published report' demonstrating a direct antiproliferative effect of cyclosporin A on cultured keratinocytes and fibroblasts. These authors observed a reversible, dose-dependent inhibitory effect and that the presence of serum attenuated this response. These findings were of interest to us because we previously observed the same phenomena and reporte...

A new series of pyrazole derivatives were designed by docking into vascular endothelial growth factor receptor-2 (VEGFR-2) kinase active site. The designed compounds were synthesized and evaluated for in vitro antiproliferative activity against HT-29 colon and PC-3 prostate cancer cell lines, and angioinhibitory activity in chorioallantoic membrane (CAM) model. Based on the obtained antiprolife...

Objectives: The predictive value of some preoperative inflammatory markers for postoperative infective complications in urinary system stone disease has been demonstrated. We investigated how valuable the systemic immune-inflammation index (SII) is as a marker development response syndrome (SIRS) patients undergoing ureteroscopy. Methods: data 495 who met study criteria were evaluated retrospec...

Erythropoietin (EPO) was first known as a factor for red blood cell proliferation and differentiation. Recent studies show the effects of EPO on immune system. In this study the antihuman leukocyte antibody (anti-HLA) titer were determined in five groups of rats, which had been sensitized with human lymphocyte. Also, the effects of stimulation's frequency and dose of recombinant human erythropo...

Objective: The study aims to demonstrate the usability of admission hematological parameters in prognosis COVID-19 infection pregnant population and introduce cut-offs values these for women.Methods: cohort this retrospective consisted 71 PCR positive women who were hospitalized Ordu University Medical Faculty Training Research Hospital between 1 May 2020 2021. divided into two groups based on ...