Radiation pneumonitis (RP) is the most significant complication of acute treatment-related toxicities in lung cancer. Intensity-modulated radiotherapy (IMRT) with inverse planning enables us to achieve the desired dose distribution. However, there are many high-risk procedures associated with lung irradiation, including chemotherapy and surgery. We report a case of fatal treatment-related pneum...

The presence of two intact lungs makes it challenging to reach a tumoricidal dose with hemithoracic pleural intensity-modulated radiation therapy (IMRT) in patients with malignant pleural mesothelioma (MPM) who underwent pleurectomy/decortications or have unresectable disease. We developed an anatomy-based model to predict attainable prescription dose before starting optimization. Fifty-six cli...

Lung cancer is the leading cause of cancer mortality in the United States. Significant effort has been carried out in developing highly conformal dose delivery techniques using multiple coplanar beams for these patients. IMRT is being used for lung cancer treatment and has shown the potential to deliver a highly conformal dose to the target while minimizing dose to the healthy tissues and is th...

INTRODUCTION Inverse-planned intensity modulated radiation therapy (IP-IMRT) has potential benefits over other techniques for tangential intact breast radiotherapy. Possible benefits include increased homogeneity, faster planning time, less inter-planner variability and lower doses to organs at risk (OAR). We therefore conducted a pilot study of previously treated intact breast patients to comp...

Treatment of the internal mammary chain (IMC) with radiation therapy (RT) for patients with breast cancer remains a controversial issue. Different treatment techniques have been proposed, including oblique electrons, electron-photon combination, and partially wide tangents (PWTs). However, the residual heart dose can remain significant mainly for left-sided lesions. With PWTs and intensity-modu...

BACKGROUND This study investigates the use of TomoDirect™ 3DCRT for whole breast adjuvant radiotherapy (AWBRT) that represents a very attractive treatment opportunity, mainly for radiotherapy departments without conventional Linacs and only equipped with helical tomotherapy units. METHODS Plans were created for 17 breast cancer patients using TomoDirect in 3DCRT and IMRT modality and field-in...

PURPOSE To quantify the dosimetric impact of four-dimensional computed tomography (4D-CT) pulmonary ventilation imaging-based functional treatment planning that avoids high-functional lung regions. METHODS AND MATERIALS 4D-CT ventilation images were created from 15 non-small-cell lung cancer patients using deformable image registration and quantitative analysis of the resultant displacement v...

The purpose of this study was to evaluate the capabilities of DMLC to deliver the respiratory motion-synchronized dynamic IMRT (MS-IMRT) treatments under various dose rates. In order to create MS-IMRT plans, the DMLC leaf motions in dynamic IMRT plans of eight lung patients were synchronized with the respiratory motion of breathing period 4 sec and amplitude 2 cm (peak to peak) using an in-hous...

The aim of this study was to identify a rational strategy for the selection of multi-beam IMRT in patients with right breast cancer through the comparison of dosimetric parameters of the planning target volume (PTV) and organs at risk (OARs) using five different radiotherapy modalities. This was a retrospective study using computed tomography scans from ten patients with early-stage right breas...

Purpose or Objective: Intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) are widely used in the treatment of advanced stage non-small cell lung cancer (NSCLC). These techniques deliver conformal dose distributions at the cost of increased target dose heterogeneity (particularly IMRT) and larger volumes of surrounding healthy tissues receiving low doses (par...