aims: the aim of the present work is (1) to evaluate dose calculation accuracy of two commonly used algorithms for 15 mv small photon fields in a medium encompassing heterogeneity and (2) compare these results with measured results obtained using gafchromic film ebt2. materials and methods: authors employed kailwood (pinus wallichiana) to mimic lung. briefly, seven kailwood plates, each measuri...

The present study was aimed at elucidating the protective effect of ferulic acid (FA), a natural polyphenol against nicotine-induced tissue damage, including lung, liver and kidney of experimental rats. Female albino rats of Wistar stain were used for the experimental study. Lung toxicity was induced by subcutaneous injection of nicotine at a dose of 2.5 mg/kg body weight (5 days a week, for 22...

Background: Bleomycin-induced lung fibrosis has been accepted as an animal model for fibrosis in rats. The aim of this study was to evaluate the effects of saffron aqueous extract on this disorder paving the way for more investigation in treating idiopathic pulmonary fibrosis in human.  Methods: Male Wistar rats (250–300 gr) were instilled a single dose of bleomycin (5 mg/kg) via in...

Introduction: Receiving exact dose by the patients is vital in radiotherapy. In radiation therapy, the dosimetry of radiations is too important because of successful radiation inquires for delivering the exact dose to the target volume. This study is to evaluate the tolerances and the accuracy of calculated dose of photon beams in the treatment software system. The TECDOC1583 p...

OBJECTIVES To report the ipsilateral lung dosimetry data of breast cancer (BC) patients treated with loco-regional hypofractionated radiotherapy (HFRT).  METHODS Treatment plans of 150 patients treated in the Radiotherapy Unit, King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia between January 2012 and March 2015 by HFRT for BC were retrospectively reviewed. All patients rece...

background: vitamin d, especially its most active metabolite 1,25-dihydroxyvitamin d₃(vit d) is essential in regulating a wide variety of biologic processes, such as regulating mesangial cell activation. the objective of this study was to assess the histopathological changes of effectiveness of vit d as a protective agent against radiation induced lung injury. materials and methods: eighteen wi...

Background:  In this study a series of basic dosimetric properties of a low-density (LD) gel dosimeter are investigated. The dose response is studied regarding to linearity, sensitivity, dose-rate and energy dependence as well as lung tissue equivalence. Materials and Methods: The LD gel was made by mixing the polymer gel with expanded polystyrene spheres. Energy dependence was studied...

PURPOSE To develop an automated technique for evaluating lung stereotactic body radiotherapy (SBRT) plan quality and predicting achievable lung dose constraints. METHODS We examined the workflow scripting capabilities of a radiation oncology software package (MIM Software Inc) for automatically generating mean dose gradients and overlap volume histograms (OVHs) for lung SBRT plans. Mean dose ...

Aims: The aims of the present work are (1) to evaluate dose calculation accuracy of two commonly used algorithms for 15 MV small photon fields in a medium encompassing heterogeneity and (2) to compare them with measured results obtained from gafchromic film EBT2.Materials and Methods: Authors employed kailwood (Pinus Wallichiana) to mimic lung. Briefly, seven Kailwood plates, each measuring 25x...

Background: The dosimetric parameters required in lung cancer radiation therapy are taken from a homogeneous water phantom; however, during treatment, the expected results are being affected because of its inhomogeneity. Therefore, it becomes necessary to quantify these deviations.Objective: The present study has been undertaken to find out inter- and intra- lung density variations and its dosi...