نتایج جستجو برای: ltb

تعداد نتایج: 643  

Journal: :The Journal of Experimental Medicine 2005
Charlotte L. Weller Sarah J. Collington Jeremy K. Brown Hugh R.P. Miller Adam Al-Kashi Peter Clark Peter J. Jose Adele Hartnell Timothy J. Williams

Mast cells are tissue-resident cells with important functions in allergy and inflammation. Pluripotential hematopoietic stem cells in the bone marrow give rise to committed mast cell progenitors that transit via the blood to tissues throughout the body, where they mature. Knowledge is limited about the factors that release mast cell progenitors from the bone marrow or recruit them to remote tis...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006
Koichiro Wada Makoto Arita Atsushi Nakajima Kazufumi Katayama Chiho Kudo Yoshinori Kamisaki Charles N Serhan

Leukotrienes (LTs) and lipoxins (LXs) are lipid mediators that play a key role in regulating acute inflammatory responses. Their roles in neural stem cell (NSC) functions are of interest. We showed here that LTB(4) and LXA(4) regulated proliferation and differentiation of murine NSCs that were isolated from embryo brains. Proliferation of NSCs was stimulated by LTB(4) (3 to 100 nM) and blocked ...

Journal: :Investigative ophthalmology & visual science 2010
Ramaprasad Talahalli Simona Zarini Nader Sheibani Robert C Murphy Rose A Gubitosi-Klug

PURPOSE Evidence suggests that capillary degeneration in early diabetic retinopathy results from chronic inflammation, and leukotrienes have been implicated in this process. The authors investigated the cellular sources of leukotriene biosynthesis in diabetic retinas and the effects of hyperglycemia on leukotriene production. METHODS Retinas and bone marrow cells were collected from diabetic ...

Journal: :The Journal of pharmacology and experimental therapeutics 2002
James F Kachur Leslie J Askonas Doreen Villani-Price Nayereh Ghoreishi-Haack Suzanne Won-Kim Chi-Dean D Liang Mark A Russell Walter G Smith

Leukotriene (LT) A(4) hydrolase is a dual function enzyme that is essential for the conversion of LTA(4) to LTB(4) and also possesses an aminopeptidase activity. SC-57461A (3-[methyl[3-[4-phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl) is a potent inhibitor of human recombinant LTA(4) hydrolase (epoxide hydrolase and aminopeptidase activities, K(i) values = 23 and 27 nM, respectively) as ...

Journal: :Electrophoresis 2004
Chih-Hsin Tsai Ching Fang Ju-Tsung Liu Cheng-Huang Lin

Low-temperature and ambient-temperature nonaqueous stacking techniques in capillary electrophoresis (CE) are described for the first time. A low-temperature bath was used to control the temperature from ambient to subzero degrees, by which a novel hyphenated method, low-temperature bath-nonaqueous capillary electrophoresis stacking (LTB-NACE stacking) is demonstrated. 3,4-Methylenedioxymethamph...

2017
Nan Sun Rongguang Zhang Guangcai Duan Xiaoyan Peng Chen Wang Qingtang Fan Shuaiyin Chen Yuanlin Xi

BACKGROUND Recent researches have been focusing on mucosal immune adjuvants, which play the key roles in mucosal immunization and have become the limitation for non-injected vaccine development. Escherichia coli heat-labile enterotoxin B subunit (LTB) was regarded as a promising mucosal adjuvant for its nontoxicity and potent activity. LTB preparation issues have always been recurring, in part ...

Journal: :Experimental lung research 2002
Gayle E Hosford Kim S Koyanagi Wynne I Leung David M Olson

In this study, the authors examined in newborn rat lung tissues the release of leukotriene B(4) (LTB(4)) from tissue explants in vitro, the protein expression of the LT-synthesizing enzyme, 5-lipoxygenase (5-LO), and its activating protein (FLAP), and the effects of in vivo hyperoxic exposure (>95% O(2)) on these parameters. Basal LTB(4) output increased from 0.98 ng/mgDNA/30 min at day 1 to 3....

Journal: :Journal of immunology 2009
Arezoo Daryadel Shida Yousefi David Troi Inès Schmid Jan Schmidt-Mende Carlo Mordasini Clemens A Dahinden Andrew Ziemiecki Hans-Uwe Simon

Leukotriene B(4) (LTB(4)) is an important proinflammatory lipid mediator generated by neutrophils upon activation. GM-CSF stimulation is known to enhance agonist-mediated LTB(4) production of neutrophils within minutes, a process called "priming". In this study, we demonstrate that GM-CSF also limits the production of LTB(4) by neutrophils via a transcriptional mechanism at later time points. W...

عزیزی جلیلیان, فرید , اولاد, غلامرضا , رضایی, احسان , سعادتی, مجتبی , سلیمیان, جعفر , میری, علی , نظریان , شهرام,

مقدمه: توکسین حساس به حرارت(LT) از عوامل حدت زای باکتری اشریشیاکلی انتروتوکسیژنیک است. زیر واحد LTB، قسمت اتصال دهنده توکسین و قادر به ایجاد مصونیتی شش ماهه در انسان است. توکسین کلستریدیوم تتانی عامل بیماری کشنده کزاز است و توکسوئید آن مصونیتی ده ساله در انسان ایجاد می نماید. زیر واحد Hc قسمت اتصال دهنده و ایمونوژنیک توکسین کزاز می باشد. میزان ایمنی زایی که هر یک از زیر واحدهای نوترکیب THc و LT...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009
Hisako Hikiji Satoshi Ishii Takehiko Yokomizo Tsuyoshi Takato Takao Shimizu

Although leukotriene B(4) (LTB(4)) is produced in various inflammatory diseases, its functions in bone metabolism remain unknown. Using mice deficient in the high-affinity LTB(4) receptor BLT1, we evaluated the roles of BLT1 in the development of two bone resorption models, namely bone loss induced by ovariectomy and lipopolysaccharide. Through observations of bone mineral contents and bone mor...

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