It has been reported that the binding of tritiated LSD (at 2 or 4 nm) to frontal cortex is reduced in schizophrenia, a finding that has been interpreted as a reduction in the number of serotonin receptors. The present study, however, reveals in a Scatchard analysis of tritiated LSD binding in frontal cortex in the brains of 13 schizophrenic patients that there was no decrease in binding by comp...

Systemic administration of lysergic acid diethylamide (LSD) to rats induces a behavioral syndrome--consisting of tremor, rigidity, Straub tail, hindlimb abduction, lateral head weaving and reciprocal forepaw treading--which is a reflection of increased activation of central serotonin receptors. Utilizing this behavioral measure, a marked supersensitivity to LSD was observed in rats whose seroto...

Although lysergic acid diethylamide (LSD), the hallucinogenic agent, has been the subject of numerous investigations, little is known about its biologic fate. In recent studies Boyd et al.’ and St011 el ~1.2 have examined the tissue distribution of CL4-labeled LSD in mice. Stoll and his co-workers2 have shown that the Cr4-labeled material measured in tissues included LSD, as well as transformat...

In the last decade, a serious new dimension has been added to the LSD controversy. A number of scientific papers have been published indicating that LSD might cause structural changes in the chromosomes, genetic mutations, disturbances of embryonic development, and malignant degeneration of cells. However a comparable number of publications question the accuracy of these allegations. Some are i...

The common assumption in potato virus epidemiology is that all daughter tubers produced by plants coming from infected mother tubers (secondary infection) will become infected via systemic translocation of the virus during growth. We hypothesize that depending on the prevalent environmental conditions, only a portion of the daughter tubers of a plant that is secondarily infected by viruses may ...

Carotid Artery Occlusion Following Ingestion of LSD • A 20-year-old white woman developed a left hemiplegia following the ingestion of LSD. Initial angiography revealed marked constriction of the internal carotid artery at the level of the siphon which, in a few days, was converted to occlusion of the carotid artery at that level. It is suggested that LSD, an amine derivative of the ergot alkal...

Because of conflicting results in the literature, further studies are needed to confirm an association between the degree of salt consumption and insulin sensitivity. The aim of this study was to measure insulin sensitivity in rats fed from weaning to adulthood with a low (LSD), normal (NSD), or high (HSD) salt diet. Body weight, carcass lipid content, blood glucose, nonesterified fatty acids, ...

The proliferation and differentiation of muscle precursor cells require myogenic regulatory factors and chromatin modifiers whose concerted action dynamically regulates access to DNA and allows reprogramming of cells towards terminal differentiation. Type 2 deiodinase (D2), the thyroid hormone (TH)-activating enzyme, is sharply upregulated during myoblast differentiation, whereas type 3 deiodin...

to experience ‘an extremely stimulated imagination’ caused by an accidental ingestion of LSD. Three days later, on April 19, 1943, he decided to verify his results by intentionally ingesting LSD. This day has become known as ‘Bicycle Day’ as Hofmann experienced an incredible bicycle ride on his way home from the lab. LSD was initially hailed as a wonder drug for use in psychoanalysis, particula...