Acute myelogenous leukemia (AML) arises from a rare population of leukemia stem cells (LSC), which were initially characterized based on their CD34+CD38immunophenotype and xenotransplantation in NOD/SCID mice (Bonnet et al., 1997). LSC are largely quiescent and refractory to traditional cell cycle-dependent agents contributing to poor long-term survival and continuous relapse. They share proper...

In this study we investigated the effects of low intensity static radiofrequency electromagnetic field (EMF) causing no thermal effects, on leiomyosarcoma cells (LSC), isolated from tumors of fifteen Wistar rats induced via a 3,4-benzopyrene injection. Electromagnetic resonance frequencies measurements and exposure of cells to static EMF were performed by a device called multi channel dynamic e...

CONTEXT Abdominal sacrocolpopexy (ASC) represents the superior treatment for apical pelvic organ prolapse (POP) but is associated with increased length of stay, analgesic requirement, and cost compared with transvaginal procedures. Laparoscopic sacrocolpopexy (LSC) and robot-assisted sacrocolpopexy (RSC) may offer shorter postoperative recovery while maintaining equivalent rates of cure. OBJE...

We report on the influence of rotation about a vertical axis on the large-scale circulation (LSC) of turbulent Rayleigh–Bénard convection in a cylindrical vessel with aspect ratio Γ ≡ D/L = 0.50 (where D is the diameter and L the height of the sample). The working fluid is water at an average temperature Tav = 40 ◦C with a Prandtl number Pr = 4.38. For rotation rates Ω . 1 rad s−1, correspondin...

Training Status Diverges Muscle Diacylglycerol Accumulation During Free Fatty Acid 2 Elevation 3 4 Short title: Training Effects on Muscle Lipid During FFA Elevation 5 6 7 Lisa S Chow1 8 Douglas G. Mashek2 9 Erin Austin 3 10 Lynn E. Eberly 3 11 Xuan-Mai Persson 12 Mara T. Mashek 2 13 Elizabeth R. Seaquist 1 14 Michael D. Jensen 15 16 1 Department of Medicine, University of Minnesota, Minneapoli...

To understand the precise disease driving mechanisms in acute myeloid leukemia (AML), comparison of patient matched hematopoietic stem cells (HSC) and leukemia stem cells (LSC) is essential. In this analysis, we have examined the value of aldehyde dehydrogenase (ALDH) activity in combination with CD34 expression for the separation of HSC from LSC in 104 patients with de novo AML. The majority o...

Fair and meaningful device performance comparison among luminescent solar concentrator-photovoltaic (LSC-PV) reports cannot be realized without a general consensus on reporting standards in LSC-PV research. Therefore, it is imperative to adopt standardized characterization protocols for these emerging types of PV devices that are consistent with other devices. This commentary highlights several...

Leukemia progression and relapse is fueled by leukemia stem cells (LSC) that are resistant to current treatments. In the progression of chronic myeloid leukemia (CML), blast crisis progenitors are capable of adopting more primitive but deregulated stem cell features with acquired resistance to targeted therapies. This in turn promotes LSC behavior characterized by aberrant self-renewal, differe...