The lipid molecule, lysophosphatidylinositol (LPI), is hypothesised to form part of a novel lipid signalling system that involves the G protein-coupled receptor GPR55 and distinct intracellular signalling cascades in endothelial cells. This work aimed to study the possible mechanisms involved in LPI-evoked cytosolic Ca(2+) mobilization in human brain microvascular endothelial cells. Changes in ...

Lysinuric protein intolerance (LPI) is an inborn error of metabolism which usually presents in infancy with failure to thrive and vomiting. Two patients are described who presented in adult life with hyperammonaemic coma due to LPI. Both had been underweight and had had intermittent gastrointestinal symptoms during childhood. They were of normal intellect and had maintained good health, until p...

STUDY OBJECTIVES To evaluate the pulmonary manifestations and the course of acute respiratory insufficiency associated with lysinuric protein intolerance (LPI). DESIGN Retrospective review of clinical data and chest radiographs (total 225) obtained during the lifetime follow-up of 31 LPI patients. About half of the 25 patients without respiratory symptoms underwent high-resolution computed to...

OBJECTIVES To assess whether pulse pressure (PP) is associated, independently of mean arterial pressure (MAP), with perivascular spaces (PVS), lacunar lesions presumably ischemic (LPI), and white matter hyperintensity volume (WMHV) seen on brain MRI. METHODS Participants in the Northern Manhattan Study had their blood pressure (BP) taken during their baseline enrollment visit and again during...

This paper presents Higher Order Spectral Analysis (HOSA) and Artificial Neural Network techniques for identification of LPI (Low Probability of Intercept) Radar signal. Common Spectral analysis and conventional methods fail to detect low powered emissions of LPI Radars and even normal radars in noisy environments. This leads us to use Higher Order Spectral Analysis (HOSA) techniques (bi-spectr...

This study characterizes the leachates quality of an active dumpsite in Warri, Delta State and also analyses its contamination or pollution potential. Leachate Pollution Index (LPI) a tool for quantifying pollution potential of leachates generated from dumpsites has been used to quantify the leachates contamination potential of the dumpsite. The LPI values for the different sample locations L1,...

The Low Probability of Intercept (LPI) capability of the radar defeats conventional RWR/ESM systems. The important advantage of LPI radar is to go undetected, while maintaining a strong battlefield awareness. Common Spectral analysis and conventional methods fail to detect emissions of LPI Radars and even normal radars in noisy environments. This leads to use Higher Order Spectral Analysis (HOS...

The retention of foetal membranes (RFM) is supposed to be related to oxidative stress which can be evaluated through indirect and direct parameters, among others, total antioxidant capacity (TAC) and lipid peroxidation intensity (LPI). Placental samples (maternal and foetal parts) were collected from Holstein-Friesian healthy cows immediately after caesarean section (n = 13, group A) at time or...

1119, LPI, Houston (CD-ROM). Markiewicz W. J., Mizuno H., and Völk H. J. (1991) Astron. Astrophys., 242, 286-289. Marshall J. and Cuzzi J. (2001) Lunar Planet. Sci., XXXII, 1262, LPI, Houston.Marshall J., Sauke T. A., and Cuzzi J. N. (2005) Geophys. Res. Lett.,

BACKGROUND Pulmonary alveolar proteinosis (PAP) is a syndrome with multiple etiologies and is often deadly in lysinuric protein intolerance (LPI). At present, PAP is treated by whole lung lavage or with granulocyte/monocyte colony stimulating factor (GM-CSF); however, the effectiveness of GM-CSF in treating LPI associated PAP is uncertain. We hypothesized that GM-CSF and surfactant protein D (S...