What diet is best for weight loss? This question has been hotly debated for decades, and answering it correctly is becoming increasingly important in view of the rising prevalence of obesity worldwide. Previous recommendations to consume low-fat diets might have been ill advised, especially if dietary fat is replaced by refi ned carbohydrates. In The Lancet Diabetes & Endocrinology, Deirdre Tob...

The effects on energy balance and brown adipose tissue thermogenesis of feeding high fat diets of differing fatty acid composition have been investigated in lean and genetically obese (ob/ob) mice. Groups of mice were fed either a low fat diet or a high fat diet based on corn oil or beef tallow for 2 wk. Energy intake and body weight gain were higher in both lean and obese animals fed the high ...

the objective of this study was to evaluate the effects of supplementation of different level protein diets with rumen protected methionine and lysine on performance and ruminal parameters in holstein dairy cows when in their early lactation. twenty one dairy cows in their early lactations were assigned to three treatments in a randomized block design experiment of a 35-d duration period. diets...

BACKGROUND Total fat and omega-3 fatty acids in the diet may affect breast cancer risk by altering estrogen metabolism. The purpose of this study was to elucidate the effects of differing total fat and omega-3 fatty acid content of diets on a panel of urinary estrogens and metabolites. FINDINGS A controlled, cross-over feeding trial was conducted in postmenopausal women using three test diets...

UNLABELLED Low-carbohydrate, high-fat (LC-HF) diets are popular for inducing weight loss in overweighed adults. Adaptive thermogenesis increased by specific effects of macronutrients on energy expenditure has been postulated to induce this weight loss. We studied brown adipose tissue (BAT) morphology and function following exposure to different LC-HF diets. METHODS Male Wistar rats were fed a...

The nutritional factors which affect lead absorption have been studied. Synthetic diets of known composition were compounded to contain 0-075% Pb as PbCl2 labelled with 203Pb. Rats were exposed to lead for periods of 48 hr. The dietary intake was then measured and the absorption of lead determined by means of a whole-body counter. Lead absorption was increased by high fat, low mineral, low prot...

Fat-rich diets not only induce obesity in humans but also make animals obese. Therefore, animals that accumulate body fat in response to a high-fat diet (especially rodents) are commonly used in obesity research. The effect of dietary fat on body fat accumulation is not fully understood in zebrafish, an excellent model of vertebrate lipid metabolism. Here, we explored the effects of dietary fat...

Results: Sixty participants (82%) in the low-fat group and 59 (79%) in the low-carbohydrate group completed the intervention. At 12 months, participants on the low-carbohydrate diet had greater decreases in weight (mean difference in change, "3.5 kg [95% CI, "5.6 to "1.4 kg]; P # 0.002), fat mass (mean difference in change, "1.5% [CI, "2.6% to "0.4%]; P # 0.011), ratio of total–high-density lip...

In recent years, it has become apparent that low-grade vascular inflammation plays a key role in all stages of the pathogenesis of atherosclerosis. Weight loss has been shown to improve blood inflammatory markers; however, it is unknown if weight-loss diets varying in macronutrient composition differentially affect inflammatory responses. The primary purpose of the present study was to compare ...

OBJECTIVE Genetic variants near IRS1 are associated with features of the metabolic syndrome (MetS). We examined whether genetic variants near IRS1 might modulate the effects of diets varying in fat content on the MetS status in a 2-year weight-loss trial. RESEARCH DESIGN AND METHODS Two variants near IRS1, rs1522813 and rs2943641, were genotyped in 738 overweight/obese adults (age 60 ± 9 year...