The main pharmacological aspects of pharmacodynamics (PD) and pharmacokinetics (PK) of aspirin as antiplatelet agent were unravelled between the late sixties and the eighties, and low-dose aspirin given once daily has been shown to be a mainstay in the current treatment and prevention of cardiovascular disorders. Nevertheless, several PD and PK aspects of aspirin in selected clinical conditions...

In this issue of Blood, Larocca et al in a large prospective study show that thromboprophylaxis with low-dose aspirin is very effective in previously untreated myeloma patients with a low thromboembolic risk receiving lenalidomide with low-dose dexamethasone.

Background For radiological protection and control, the International Commission on Radiological Protection (ICRP) provides nominal risk coefficients related to radiation exposure, which can be extrapolated using excess relative absolute obtained from Life Span Study of atomic bomb survivors in Hiroshima Nagasaki with dose dose-rate effectiveness factor (DDREF). Materials Methods Since it is im...

Whole-gland low-dose rate (LDR) brachytherapy has been a well-established modality of treating low-risk prostate cancer. Treatment in a focal manner has the advantages of reduced toxicity to surrounding organs. Focal treatment using LDR brachytherapy has been relatively unexplored, but it may offer advantages over other modalities that have established experiences with a focal approach. This is...

We thank Brasky et al. for their review (Brasky et al., 2016) of our meta-analysis on the association between NSAID use and risk of endometrial cancer (Verdoodt et al., 2016). We welcome the additional information on two of their studies, and the discussion points they have raised, which are valuable contributions to the topics discussed in our meta-analysis. Below we respond to the issues rais...

DESCRIPTION Update of the 1996 U.S. Preventive Services Task Force (USPSTF) recommendation on aspirin prophylaxis in pregnancy. METHODS The USPSTF reviewed the evidence on the effectiveness of low-dose aspirin in preventing preeclampsia in women at increased risk and in decreasing adverse maternal and perinatal health outcomes, and assessed the maternal and fetal harms of low-dose aspirin dur...