Drug impurities are now seen as a major threat to drug safety around the world, especially when it comes carcinogenic impurities. Here, we present first spectrophotometric approach for quantification of lignocaine and fluorescein in presence 2,6-xylidine, lignocaine’s impurity. The depends on overcoming unresolved bands through data processing strategy employing 10 affordable, simple, sensitive...

Angiotensin receptor blockers (ARBs) are the first-line antihypertensive agents. In clinical practice, it is often difficult to achieve the recommended blood pressure level by ARBs in their ordinal dosages alone. This study examined the practical efficacy of a combination therapy of ARB with thiazide diuretics for lowering morning home blood pressure (MHBP) in comparison to high-dose ARB therap...

Two new simple and selective assay methods have been presented for the analysis of eprosartan mesylate (EPR) and hydrochlorothiazide (HCT) in pharmaceutical formulations. The first method is based on first-derivative ultraviolet spectrophotometry with zero-crossing measurements at 246 and 279 nm for EPR and HCT, respectively. The assay was linear over the concentration ranges 3.0-14.0 µg/mL for...

The significant spectral overlap (Di) 0.5 = 0.5667 which is about 75.3% overlapping of the UV/Visible absorption spectra of iron (II) and copper (II) complexes necessitates chemometric assisted methods for simultaneous analysis of these ions in the pharmaceutical mixture. These metal ions were analyzed simultaneously by UV/Visible spectrophotometric method where 8-hydroxyquinoline was used as a...

In this study, zero-, first-, secondand third-order derivative spectrophotometric methods were developed for quantitave determination of atenolol in pharmaceutical preparation. In zero order spectrophotometry, absorbance values were measured at 276 nm in zero order spectra of solution of atenolol in methanol in the range of 245-310 nm. In first derivative spectrophotometry, absorbance values we...

The degradation behavior of cefixime trihydrate was investigated under different stress conditions of acidic hydrolysis, alkaline hydrolysis and oxidation using spectrophotometry. Stability indicating spectrophotometric methods were developed that could separate the drug from its degradation products formed under these stress conditions. The UV spectral characteristics of the drug and degraded ...

Aims: A simple and highly sensitive LC-MS method was used to determine the concentrations of losartan, its major active metabolite E3174 and hydrochlorothiazide in human plasma and pharmacokinetic characteristics and metabolism phenotype observation after administration of losartan tablets and losartan/hydrochlorothiazide combination tablets. Methods: An open, randomized cross-over single-dose ...

The present article describes the potential utility of derivative ultraviolet (UV) spectrophotometric technique to detect petroleum products (gasoline, kerosene and diesel) in fire debris residues. Derivative UV spectra of these petroleum products were recorded in their neat state, and compared with those obtained from fire debris samples in order to distinguish them. Derivative UV spectrophoto...

The present work aims to develop a spectrophotometric method for simultaneous estimation of melatonin and Vitamin C in combined dosage form. Absorbance of melatonin and Vitamin C were measured at the absorbance maximum (λ max) at 278 and 256 nm, respectively. The coefficient of correlation for melatonin at 278 nm and Vitamin C at 256 nm is 0.9986 and 0.9968, respectively. A linear relation betw...