clinical studies suggest that essential oil of eugenia caryophyllata (clove) buds (eoec) is efficacious in the treatment of dental pain. in the present study, we investigated the analgesic and local anesthetic effects of eoec and its possible mechanisms of action in acute corneal pain in rats. eoec was extracted by hydro-distillation in a clevenger type apparatus from clove buds. the acute corn...

BACKGROUND Laparoscopic cholecystectomy (LC) has become the treatment of choice for gallbladder lesions, but it is not a pain-free procedure. This study explored the pain relief provided by combined wound and intraperitoneal local anesthetic use for patients who are undergoing LC. METHODS Two-hundred and twenty consecutive patients undergoing LC were categorized into 1 of the following 4 grou...

introduction: failure to achieve adequate and profound anesthesia in teeth with acute pulp inflammation is a common condition during emergency visits in root canal therapy. many different anesthetic solutions such as morphine and capsaicin have accordingly been examined. mannitol­ an alcoholic sugar with high osmotic pressure level- is applicated for reducing intracranial and post retinal press...

Accurate detection of the degree isoflurane anesthesia during a surgery is important to avoid risk overdose timely. To address this challenge, four-shank implantable microelectrode array (MEA) was fabricated for synchronous real-time dual-mode signals [electrophysiological signal and dopamine (DA) concentration] in rat striatum. The SWCNTs/PEDOT:PSS nanocomposites were modified onto MEAs, which...

We have shown previously that prenylamine, a calcium channel blocker, has potent local anesthetic activity in vivo and in vitro. We now characterize the tonic and use-dependent block of prenylamine on wild-type human cardiac voltage-gated sodium channels (hNav1.5) transiently expressed in human embryonic kidney 293t cells under whole-cell voltage-clamp condition. We also determine whether preny...

background. given the influence of systemic blood pressure on pulpal blood flow, anxiolytics prescribed may alter the pulpal blood flow along with the local anesthetic solution containing a vasoconstrictor. this study evaluated the impact of preoperative anxiolytics and vasoconstrictors in local anesthetic agents on pulpal oxygen saturation. methods. thirty anxious young healthy individuals wit...

Epidural solutions of local anesthetics and opioids, such as bupivaCaine and fentanyl, are commonly employed for intraoperative use, labor and delivery, and postoperative analgesia. Clinicians frequently need to assemble mixtures of different concentrations from individual components. Knowing the initial and final concentrations of local anesthetic and opioid, this method allows one to quickly ...

BACKGROUND AND OBJECTIVES Local anesthetics are used broadly to prevent or reverse acute pain and treat symptoms of chronic pain. Local anesthetic-induced cardiotoxic reaction has been considered the accidental event without currently effective therapeutic drugs except for recently reported intralipid infusion whose possible mechanism of action is not well known. CONTENTS Cardiolipin, an anio...

Patients with a history of adverse reactions to a local anesthetic may often be incorrectly labeled as "allergic." Determining if a patient is allergic to a local anesthetic is essential in the selection of appropriate pain control techniques. Local anesthetic allergy testing may be performed safely and with reasonable accuracy by a knowledgeable practitioner. This paper presents guidelines for...