Introduction: This study was performed to evaluate the effects of intra-nucleus accumbens shell microinjection of Larginine (NO precursor) and L-NAME (nitric oxide synthase (NOS) inhibitor) on morphine withdrawal signs in male rats. Method: Rats were anaesthetized with a combination of ketamine and xylazine, and placed in stereotaxic apparatus, and a guide cannula was inserted into nucleus accu...

McCord, Gregg R., Jean-Luc Cracowski, and Christopher T. Minson. Prostanoids contribute to cutaneous active vasodilation in humans. Am J Physiol Regul Integr Comp Physiol 291: R596–R602, 2006. First published February 16, 2006; doi:10.1152/ajpregu.00710.2005.— The specific mechanisms by which skin blood flow increases in response to a rise in core body temperature via cutaneous active vasodilat...

This study investigated the gastroprotective effect of Lcarnitine against indomethacin-induced gastric ulcer in rats and the possible mechanisms underlying this effect. Two sets of experiments were performed. In the first set male albino rats (170-210 g) were randomly allocated into a normal control group, ulcer control group (received a single dose of indomethacin 30 mg/kg po) and three ulcer ...

Aims—To investigate the eVects of chronic administration of nitric oxide synthase inhibition on ocular blood flow and metabolic demand in the rat and to compare these eVects with changes in the cerebral and peripheral circulation. Methods—Male Sprague-Dawley rats were injected with the nitric oxide synthase inhibitor L-NAME (75 mg/kg ip), either on a single occasion only or once daily for 10 co...

THE MAINTENANCE OF A CONSTANT RENAL BLOOD FLOW and glomerular filtration rate in the face of physiological changes and pathological states is essential for proper fluid and electrolyte homeostasis. This phenomenon has been named renal autoregulation and is comprised of two major mechanisms, the myogenic response and tubuloglomerular feedback. The myogenic response is not unique to the kidney an...

In their intriguing article appearing in this issue of Hypertension, Yu et al1 provide evidence for a role of T lymphocytes in modulating cardiac matrix remodeling resulting from hypertension. The investigators compared the impact of comparable N -nitro-L-arginine methyl ester (LNAME)–induced hypertension on cardiac function and matrix composition among 3 strains of mice with widely different T...

The vasodilator activity of a1-adrenoceptor agonists was tested in the rat mesenteric vascular bed (MVB), and the mechanism involved was investigated in cultured endothelial cells isolated from the bovine coronary vascular bed. In preparations preconstricted by U46619, noradrenaline and phenylephrine induced a slight relaxant effect at nanomolar concentrations. This effect was abolished in endo...

Peroxisome proliferator-activated receptor / (PPAR) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily that regulates the transcription of many target genes. More recently, acute, nongenomic effects of PPARagonists have also been described. In the present study, we hypothesized that PPARagonists might exert acute nongenomic effects on vascular tone....

The Census Coverage Measurement survey-based program estimated household population coverage of the 2010 Decennial Census. Calculating coverage estimates required linking survey person data to census enumerations. For record linkage research, we applied a Bayesian Latent Class Models approach to both 2010 coverage survey data and simulated household data. This paper presents our use of Base SAS...

Endothelial nitric oxide synthase (eNOS), which generates the endogenous vasodilator, nitric oxide (NO), is highly regulated by post-translational modifications and protein interactions. We recently used purified proteins to characterize the mechanisms by which heat shock protein 90 (HSP90) increases eNOS activity at low and high Ca levels (Takahashi, S. and Mendelsohn, M. E., J. Biol. Chem. 27...