We present the analysis of an approximately 3 year long Rossi X-ray Timing Explorer (RXTE) monitoring campaign of the canonical soft state black hole candidates LMC X-1 and LMC X-3. In agreement with previous observations, we find that the spectra of both sources can be well-described by the sum of a multi-temperature disk blackbody and a power law. In contrast to LMC X-1, which does not exhibi...

We present a detailed analysis of the uncertainty on the theoretical population corrections to the LMC Red Clump (RC) absolute magnitude, by employing a population synthesis algorithm to simulate theoretically the photometric and spectroscopic properties of RC stars, under various assumptions about the LMC Star Formation Rate (SFR) and Age Metallicity Relationship (AMR). A comparison of the out...

Repulsive Eph forward signaling from limb-derived ephrins guides the axons of lateral motor column (LMC) motor neurons. LMC axons also express ephrinAs, while their EphA receptors are expressed in the limb mesenchyme. In vitro studies have suggested that reverse signaling from limb-derived EphA4 to axonal ephrinAs might result in attraction of LMC axons. However, genetic evidence for this funct...

Purpose Early diagnosis of leptomeningeal carcinomatosis (LMC) is necessary to improve outcomes of this formidable disease. However, cerebrospinal fluid (CSF) cytology is frequently false negative. We examined whether CSF metabolome profiles can be used to differentiate patients with LMC from patients having a risk for development of LMC. Results A total of 10,905 LMIs were evaluated using PC...

Leptomeningeal carcinomatosis (LMC) remarkably decreases the quality of life of EGFR-mutant lung cancer patients. In contrast to the lesions outside the central nervous system (CNS), molecular mechanisms of EGFR tyrosine kinase inhibitor (TKI) resistance in CNS lesions including LMC are largely unknown. In this study, we established an in vivo imaging model for LMC with EGFR mutant lung cancer ...

The emergence of limb-driven locomotor behaviors was a key event in the evolution of vertebrates and fostered the transition from aquatic to terrestrial life. We show that the generation of limb-projecting lateral motor column (LMC) neurons in mice relies on a transcriptional autoregulatory module initiated via transient activity of multiple genes within the HoxA and HoxC clusters. Repression o...

We study the effect of reddening on microlensed stars towards the LMC. If lenses are in the LMC disk, then the source stars should be at the far side or behind the LMC disk. Thus they should experience more reddening and extinction by dust in the LMC disk than ordinary stars in the immediate neighbouring lines of sight. Clearly such bias would not occur if the lenses are machos in the Galactic ...

Bidirectional signaling between Eph receptor tyrosine kinases and their cell-surface protein signals, the ephrins, comprises one mechanism for guiding motor axons to their proper targets. During projection of motor axons from the lateral motor column (LMC) motor neurons of the spinal cord to the hindlimb muscles in chick embryos, ephrin-A5 has been shown to be expressed in the LMC motor axons u...

We present a morphological analysis of the feature-rich 2MASS LMC colormagnitude diagram, identifying Galactic and LMC populations and estimating the density of LMC populations alone. We also present the projected spatial distributions of various stellar populations. The conditions that prevailed when 2MASS observed the LMC provided 10σ limiting sensitivity for J <∼ 16.3, H <∼ 15.3, Ks <∼ 14.7....

We describe BeppoSAX observations of the black hole candidates LMC X–1 and LMC X–3 performed in Oct. 1997. Both sources can be modelled by a multicolor accretion disk spectrum, with temperature ∼ 1 keV. However, there is some evidence that a thin emitting component coexists with the thick disk at these temperatures. In the direction of LMC X–1, we detected a significant emission above 10 keV, w...