Objective: Chronic ethanol consumption has significant negative effects on liver tissue. Mechanisms of ethanol toxicity include oxidative stress and inflammation. The antioxidant and anti-inflammatory properties of the lemon verbena have been proven in studies. The aim of this study was to evaluate the protective effect of hydro alcoholic extract of Aloysia citriodora (AC) on ethanol-induced he...

Excessive ethanol intakes have been reported to be linked liver diseases such as hepatitis and cancerrelated of ethanol. can lead the accumulation reactive oxygen species(ROS) depletion glutathione (GSH) in liver. Ethanol-induced oxidative stress substantiallyincreases peroxidation lipid decreases GSH levels human hepatocyte animal models.Ethanol contributes sterol regulating element-binding pr...

The unique characters of camel's milk make it used extensively in the field of medicine as anti-microbial, anti-diabetic and hepatoprotective agent. The lack of studies demonstrating the protective effect of camel's milk against hepatotoxic compound was the main reason beyond the conduction of the current experiment which aimed to investigate the protective effects of camel's milk against carbo...

Hepatic ischemia-reperfusion (I/R) is a common phenomenon during liver surgery, transplantation, infection and trauma which results in damage and necrosis of the hepatic tissue through different pathways. Mechanisms involved in I/R damage are very intricate and cover several aspects. Several factors are involved in I/R-induced damages; briefly, decrease in sinusoidal perfusion and ATP generatio...

background: in this study, the protective effect of thymoquinone (tq) and nigella sativa seeds oil (nso) was evaluated against oxidative damages induced by ethanol in rats. methods: animals were treated with ethanol 40% daily by gavages once a day for 4 weeks. nso and tq were injected intraperitoneal once a day for 4 weeks. the histopathological examination of liver, kidney, brain and heart was...

conclusions the di was found to induce liver damage by oxidative stress mechanisms. silibinin reduced the oxidative stress by inducing antioxidant mechanisms, thereby showing protective effect against di induced liver damage. further studies with silibinin should be performed regarding di toxicity. materials and methods thirty two wistar albino rats were divided into four groups, as follows: 1)...

Bioartificial liver holds special position in the field of regenerative medicine, and cold environment at 4℃ is widely used for the short storage of both organ and liver cell for later application. However, the disadvantages of such cold storage could influence cell viability and lead to cell apoptosis in different degrees. In this study, we mainly explore the pre-protective effect of mild hypo...