background hepatic fibrosis is an inclusion indicator for treatment and a major independent predictor of treatment response in patients with chronic hepatitis c. liver biopsy, considered as the “gold standard” for evaluating liver fibrosis, has carried some drawbacks. currently used noninvasive predictors of fibrosis are considered less accurate than liver biopsy. objectives our aim was to asse...

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BACKGROUND Current practice guidelines recommend liver biopsy prior to treatment of hepatitis C genotype-1 but not for genotype-2/3; this is based on expert opinion, not on published evidence. METHODS In retrospective analysis of a large trial database prior to the publication of recent guidelines, we compared outcomes in 985 treatment-naïve patients with hepatitis C who did or did not underg...

The distribution of tissue polypeptide antigen (40 kD molecular weight) in normal adult and fetal liver, and in liver disease was investigated and compared with the distribution of low and high molecular weight cytokeratins. In normal liver tissue polypeptide antigen was found only in bile duct epithelium; this distribution is similar to that of high molecular weight cytokeratin, but differs fr...

background: â  advanced hepatic fibrosis and cirrhosis has generally been considered to be irreversible. the aim of this study was to determine whether cirrhosis is reversible.â  â  methods: â  seven patients with autoimmune hepatitis with histologic evidence of cirrhosis were enrolled. after treatment, they had follow-up liver biopsy while in clinical and biochemical remission. biopsy specimen...

No agreement has been reached about the aetiology of the syndrome known as sarcoidosis, Besnier-Boeck-Schaumann disease, lymphogranulomatosis benigna, or non-caseating tuberculosis; and even those who hold decided opinions on this subject admit their inability to demonstrate the agent which they consider responsible. Hence any satisfactory definition of the group of cases to be included under t...

Liver biopsy (LB) is an important procedure in the diagnosis and treatment of liver diseases. However, procedures for performing LB vary amongst institutions, and no universal guide‐ lines exist. LB is performed for two main reasons: diagnosis of a liver condition itself, and as an adjunct to an existing surgical procedure. Recently, it has become possible to employ both approaches with minimal...

Historically, liver biopsy has been used to determine the etiology of liver disease, the degree of inflammation, the stage of liver fibrosis, and the response to treatments. In the last decade, the advent of noninvasive tests has improved the diagnosis and management of autoimmune liver diseases. For example, serum markers can identify hepatic inflammation, whereas ultrasound and MRI can diagno...

Introduction: Hepatitis B virus (HBV) infection is a global public health problem. Serum HBV DNA measurement is a non-invasive test that predicts the liver disease progression. The aim of this study was to determine the HBV DNA level and look for a relation between the HBV DNA level and liver histology. Methods: This was a cross sectional study on chronic...