we present detailed theoretical studies of the h-bonded complexes formed from interaction between 5-fluorouracil and various six-membered cyclic nitrosamine compounds. in this study, an investigation on intermolecular interactions in x-nu (x = ch2, sih2,bh, alh, nh, ph, o and s) complexes is carried out using density functional theory. the calculations are conducted on b3lyp/6-311++‏‏g** level ...

background: providing holistic nursing care when there is a shortage of personnel and equipment exposes nurses to stress and a higher risk of occupational burnout. humour can promote nurses’ health and influence nursing care. the aim of this study was to describe nurses’ experiences of humour in clinical settings and factors affecting it.   methods : this qualitative study investigated nurses’ ...

the doctor-patient interaction (dpi) plays an important role in the way patients view physicians. thus, response to the question of ''who is a great physician?'' is related to dpi experiences of patients. the aim of this qualitative study was to explore patients' views regarding this subject. based on critical ethnography in one educational hospital in shiraz, iran, the study was performed base...

the binding of drugs by plasma proteins is an important phenomenon, because it influences the size of the free fraction of the drugs in plasma. in this study the influence of dipyridamole (dp) on the protein binding of propranolol (pl) and pl on the protein binding of dp were studied alone and in the presence of nicotine (nc).        the equilibrium dialysis was employed for protein binding stu...

background: prediction of interaction sites within the membrane protein complexes using the sequence data is of a great importance, because it would find applications in modification of molecules transport through membrane, signaling pathways and drug targets of many diseases. nevertheless, it has gained little attention from the protein structural bioinformatics community. methods: in this stu...

objective: parental self-efficacy is associated with increasing mental health in children. there is a paucity of research in iran on the role of parental self-efficacy in increasing mental health status of children. in this preliminary study, we studied the effectiveness of the world health organization international child development program (2002) for children aged 3 years and younger in incr...

the interaction of brilliant green with herring sperm dna was investigated in detail by spectrometric methods in γ-cyclodextrin systems. on the condition of physiological ph, brilliant green prefers to form the 1:1 inclusion complex with γ-cyclodextrin.all the evidences indicated that the binding modes between γ-cyclodextrin-brilliant green and dna were grooving binding and partial non-classica...

introduction: interaction between drugs represents a major clinical concern for health care professionals and their patients. patients affected by both type 2 diabetes and epilepsy may be prescribed pioglitazone and an anti-epileptic drug such as phenytoin  concurrently. the aim of this study was to consider the interaction of pioglitazone with phenytoin in an experimental model. according to t...

objective:the purpose of this study was to investigate the effects of piroxicam co-administration with ethanolic stem-bark extract of khaya senegalensis on biomarkers of oxidative stress and gastro-toxicity in wistar rats. materials and methods: thirty healthy male and female albino wistar rats (190-220 g) were grouped into six (n = 5) with designated treatments including: normal saline, piroxi...

abstract- the effects of iron (fe) and zinc (zn) treatments on the growth and nutrient composition of chickpea were studied in a greenhouse experiment arranged in a completely randomized design. while the application of fe decreased mean shoot dry weight of chickpea, that of zn had no significant effect on chickpea shoot dry weight. increasing fe levels drastically decreased mn concentration an...