Sanhuang-Siwu-Tang (SST), composed of seven medicinal herbs, is a well-known herbal formula used for the treatment gynecologic diseases. To expand clinical use SST, we explored anti-inflammatory or anti-neuroinflammatory effects SST water extract in lipopolysaccharide-stimulated RAW264.7 macrophages and BV2 microglial cells. According to HPLC analysis, main components were from Scutellariae Rad...

conclusions purified lps can be considered as a safe adjuvant and can be used as a component in prophylactic and therapeutic vaccines targeting infectious disease, cancer and allergies. results biochemical analysis data and sds-page profile showed that the chemical nature of s19 lps is different from rb51 lps. both s and r-lps induce an immune response. t-cell immune response induced by both s ...

Investigation of the effects prantchimgin (Prn) compound isolated from root part Ferulago pauciradiata (Apiaceae) plant in lipopolysaccharide (LPS) cytotoxicity model created L929 cell line. lines were applied a 5% CO2 incubator at 37 °C, using standard culture procedures, LPS was with Prn pure substance final concentration 2 µL and 1 after hour. Following application, MTT protocol, colorimetri...

Propolis is a bee product used since ancient times due to its diverse biological applications. We aimed investigate the antioxidant and anti-inflammatory action of Brazilian propolis in THP-1 cells stimulated with 1‐fluoro‐2,4‐dinitrobenzene (DNFB) or lipopolysaccharide (LPS). Cell viability was assessed by resazurin assay, activity evaluated DPPH superoxide dismutase (SOD) 1 2 colorimetric ass...

Abstract Background and Aims Innate immunity inflammation were recognized as the key factors for progression of acute kidney injury (AKI) induced by lipopolysaccharide (LPS). Stimulator interferon genes (STING) has emerged a critical component innate immune inflammatory responses. This study aimed to explore role STING in LPS-induced tubular AKI. Method 1. The AKI mice models intraperitoneal in...

Background. Curcumin has a variety of properties, including antioxidant and anti-inflammatory ones, demonstrated some protective prospects on neurological conditions.
 Aim: This study explored the neuroprotective ability curcumin in lipopolysaccharide-induced neuroinflammation an animal model.
 Methods. A total thirty-two adult male mice were randomly assigned to four groups (A, B, C,...

To study the role of the redox state regulator glutathione (GSH) in bacterial lipopolysaccharide (LPS)-induced anorexia we measured total reduced GSH (trGSH) in liver, serum and brain in response to intraperitoneal (ip) lipopolysaccharide (LPS, 4 microg/mouse) injection in LPS-naïve and LPS-pretreated (4 microg/mouse given 3 days earlier) mice. LPS reduced food intake in LPS-naïve mice and LPS ...

abstract   the mutagenic and immunosuppressory effects of cyclophosphamide (cyp) are still the primary limitation to wider application for treating a variety of human malignancies. on the one hand, cyp treatment predisposes transplant recipients and cancer patients to risk of bacterial, fungal, and viral infections, in the other word the, lipopolysaccharide (lps), an endotoxin found in cell wal...

Objective: This study aims to examine the role of a probiotic bacterium, Bacillus clausii, on oxidative stress in lipopolysaccharide (LPS)-induced acute kidney injury (AKI) rat model. Materials and Methods: The rats were divided into four groups: Control group, LPS group (1.5 mg/kg, LPS), Probiotic+LPS which was given after administration clausii as for 21 days, Probiotic group. kidneys removed...