A haemorrhagic protein toxin (SA-HT) was isolated and purified from the spine extract of the Indian venomous butterfish, S. argus Linn, by two step ion exchange chromatography. The toxin was homogeneous in native and SDS-PAGE gel. SDS-molecular weight of the toxin was found to be 18.1 +/- 0.09 kDa. SA-HT produced severe haemorrhage on stomach wall but devoid of cutaneous haemorrhage. UV, EDTA, ...

It has been reported that Paulistine in the venom of the wasp Polybia paulista co-exists as two different forms: an oxidized form presenting a compact structure due to the presence of a disulfide bridge, which causes inflammation through an apparent interaction with receptors in the 5-lipoxygenase pathway, and a naturally reduced form (without the disulfide bridge) that exists in a linear confo...

Citation: Chirumbolo S and Bjørklund G (2016) Commentary: The Flavonoid Baicalein Rescues Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer's Disease. A recent article by Gu et al. reported that the long-term oral administration of baicalein in mouse, inhibited the activity of lipooxygenase 12/15 LXO and glycogen synthase kinase 3β (GSK-3β) in hippocampal slices, also reduci...

objective: it has been shown that silybum marianum or its extracts have hepatoprotective, antioxidant, anticancer, anti-inflammatory and anti-diabetic effects. nitric oxide (no) plays an important role in neurotransmission, neuroprotection, neurotoxicity and pathological pain, as a neurotransmitter or neuromodulator in the central nervous system. therefore, this experiment was performed in orde...

Objective: It has been shown that Silybum marianum or its extracts have hepatoprotective, antioxidant, anticancer, anti-inflammatory and anti-diabetic effects. Nitric oxide (NO) plays an important role in neurotransmission, neuroprotection, neurotoxicity and pathological pain, as a neurotransmitter or neuromodulator in the central nervous system. Therefore, this experiment was performed in orde...

Punica granatum (Pg), commonly known as pomegranate (Pg), is a member of the monogeneric family, Punicaceae, and is mainly found in Iran which is considered to be its primary centre of origin. Pg and its chemical components possess various pharmacological and toxicological properties including antioxidant, anti-inflammatory (by inhibiting pro-inflammatory cytokines), anti-cancer and anti-angiog...

Background and objectives: Apiaceae family is one of the largest plant families with wide distribution all around the world. The genus Hippomarathrum has 28 species around the world among them H. microcarpum is outspread in the north, northwest, west and central of Iran, and also Turkey, Caucasus and Iraq. In a previous study, two coumarins (osthole and isoimp...

punica granatum (pg), commonly known as pomegranate (pg), is a member of the monogeneric family, punicaceae, and is mainly found in iran which is considered to be its primary centre of origin. pg and its chemical components possess various pharmacological and toxicological properties including antioxidant, anti-inflammatory (by inhibiting pro-inflammatory cytokines), anti-cancer and anti-angiog...

We have used patch-clamp techniques to study the effects of arachidonic acid (AA) on the activity of the 70-pS K+ channel, the predominant type of the two apical K+ channels operating under physiological conditions in the thick ascending limb (TAL) of the rat kidney. Addition of 5-10 microM AA blocked the activity of the 70-pS K+ channel in both cell-attached and inside-out patches. The inhibit...

Citation: Chirumbolo S (2016) Commentary: Mutual interaction of basophils and T cells in chronic inflammatory diseases. A commentary on Mutual interaction of basophils and T cells in chronic inflammatory diseases Sarfati et al. recently published a thorough overview on the role exerted by basophils in the immune system and their relationship with T cells in chronic inflammation (1). In their pa...